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Health‐related Research Ethics and Social Value: Antibiotic Resistance Intervention Research and Pragmatic Risks

Artikel i vetenskaplig tidskrift
Författare Christian Munthe
Niels Nijsingh
Karl Persson de Fine Licht
D. G. Joakim Larsson
Publicerad i Bioethics
Volym 33
Nummer/häfte 3
Sidor 335-342
ISSN 0269-9702
Publiceringsår 2019
Publicerad vid Institutionen för filosofi, lingvistik och vetenskapsteori
CARe - Centrum för antibiotikaresistensforskning
Institutionen för biomedicin, avdelningen för infektionssjukdomar
Sidor 335-342
Språk en
Länkar https://doi.org/10.1111/bioe.12580
https://gup.ub.gu.se/file/207699
Ämnesord Antimicrobial resistance, Bioethics, CIOMS, Drug resistance, Helsinkki Declaration, Public health ethics, Wicked problems,
Ämneskategorier Teknik och social förändring, Forskningspolitik, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Medicinsk etik, Etik, Praktisk filosofi

Sammanfattning

We consider the implications for the ethical evaluation of research programs of two fundamental changes in the revised research ethical guideline of the Council for International Organizations of Medical Sciences. The first is the extension of scope that follows from exchanging “biomedical” for “health-related” research, and the second is the new evaluative basis of “social value,” which implies new ethical requirements of research. We use the example of antibiotic resistance interventions to explore the need to consider what we term the pragmatic risks of such interventions to evaluate the so- cial value of certain kinds of health-related research. These (pragmatic) risks severely threaten the social value of interventions in every area where human and social re- sponses significantly impact on their effectiveness. Thus, the social value of health-re- lated research needed to demonstrate its effectiveness depends on the successful management of such risks. Research designed to take into account pragmatic risks also gives rise to similar types of risks, and the potential for social value in light of those risks needs to be considered in ethical reviews based on the new guidelines. We argue that, to handle this new expanded task, the international system of research ethical review addressed by the guidelines needs institutional development. In particular, we consider lifting research ethical review to a level closer to actual health policy making.

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