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No effects of mitomycin-C in primary trabeculectomies in Sweden

Artikel i vetenskaplig tidskrift
Författare Marcelo Ayala
Publicerad i Sage Open Medicine
Volym 6
Sidor 7
ISSN 2050-3121
Publiceringsår 2018
Publicerad vid Institutionen för neurovetenskap och fysiologi
Sidor 7
Språk en
Länkar dx.doi.org/10.1177/2050312118782262
Ämnesord Mitomycin-C, glaucoma, surgery, Sweden, follow-up, visual impairment, glaucoma, complications, surgery, endophthalmitis, efficacy, safety
Ämneskategorier Oftalmologi

Sammanfattning

Aim: To evaluate the results of a long-term follow-up after two different types of surgical techniques: trabeculectomy with or without mitomycin-C. Materials and methods: This study is a retrospective chart review of patients operated on with a primary trabeculectomy at the Eye Department of the Skaraborg Hospital, Skovde, Sweden. Complete success was defined as intraocular pressure 18mmHg (criterion 1) or intraocular pressure reduction 30% (criterion 2) without eye drops postoperatively. Qualified success was defined using the same criteria (1 and 2), but patients were treated or untreated with eye-drops. Results: A total of 167 patients were included in this retrospective study, 83 patients in the no-mitomycin-C group and 84 patients in the mitomycin-C-treated group. No significant difference was found in intraocular pressure reduction between the mitomycin-C and no-mitomycin-C group (t-test; p=0.19). Complete success using criterion 1 was 66.2% in no-mitomycin-C and 62.8% in mitomycin-C (p=0.88); success using criterion 2 was 76.6% in the no-mitomycin-C and 64.2% in the mitomycin-C group (p=0.21). Qualified success using criterion 1 was 71.4% in the no-mitomycin-C and 74.4% in the mitomycin-C group (p=0.84); success using criterion 2 was 80.0% in the no-mitomycin-C and 84.4% in the mitomycin-C group. All included patients were born in Sweden. Conclusion: Mitomycin-C seems to add no benefits to intraocular pressure reduction after primary trabeculectomies in a Swedish population.

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