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Lymph node metastases as only qualifier for stage IV serous ovarian cancer confers longer survival than other sites of distant disease - a Swedish Gynecologic Cancer Group (SweGCG) study.

Artikel i vetenskaplig tidskrift
Författare Elisabet Hjerpe
Christian Staf
Pernilla Dahm-Kähler
Karin Stålberg
Maria Bjurberg
Erik Holmberg
Christer Borgfeldt
Bengt Tholander
Kristina Hellman
Preben Kjølhede
Thomas Högberg
Per Rosenberg
Elisabeth Åvall-Lundqvist
Publicerad i Acta oncologica (Stockholm, Sweden)
Volym 57
Nummer/häfte 3
Sidor 331-337
ISSN 1651-226X
Publiceringsår 2018
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för onkologi
Sidor 331-337
Språk en
Länkar dx.doi.org/10.1080/0284186X.2017.14...
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adult, Aged, Aged, 80 and over, Carcinoma, Ovarian Epithelial, Cystadenocarcinoma, Serous, mortality, pathology, Female, Humans, Kaplan-Meier Estimate, Lymphatic Metastasis, pathology, Middle Aged, Neoplasms, Glandular and Epithelial, mortality, pathology, Ovarian Neoplasms, mortality, pathology, Prognosis, Proportional Hazards Models, Sweden, epidemiology, Young Adult
Ämneskategorier Cancer och onkologi, Obstetrik och gynekologi

Sammanfattning

The International Federation of Gynecology and Obstetrics (FIGO) ovarian cancer staging system includes no sub-stage for lymph nodes (LN) as only distant disease manifestation. We explore the prognostic implication of LN as only stage IV classifier in serous ovarian cancer.This is a nation-wide, population-based study on 551 women with serous stage IV cancers diagnosed between 2009-2014. We compare overall survival (OS) in women with LN as only distant metastatic site to those with pleural metastases only and to patients with other/multiple stage IV manifestations. Cox regression models were used for uni- and multivariable estimations.Of 551stage IV cases, distant metastatic site was registered in 433. Median OS for women with LN (n = 51) was 41.4 months, compared to 25.2 and 26.8 months for patients with pleural (n = 195) or other/multiple (n = 187) distant metastases (p = .0007). The corresponding five-year survival rates were 32, 11 and 22%, respectively. Multivariable analyzes confirmed shorter survival for women with pleural (HR 2.99, p = .001) or other/multiple distant sites (HR 2.67, p = .007), as compared to LN cases. LN only patients lived 9.1 months longer after primary than after interval surgery, but this difference was not significant (p = .245).Women with stage IV serous ovarian cancer having lymph nodes as only distant metastatic site live longer than other stage IV patients.

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