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Lymph node 8a as a prognostic marker for poorer prognosis in pancreatic and periampullary carcinoma.

Artikel i vetenskaplig tidskrift
Författare Johanna Wennerblom
Pushpa Saksena
Claes Jönsson
Anders Thune
Publicerad i Scandinavian journal of gastroenterology
Volym 53
Nummer/häfte 2
Sidor 225-230
ISSN 1502-7708
Publiceringsår 2018
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för kirurgi
Sidor 225-230
Språk en
Länkar dx.doi.org/10.1080/00365521.2017.14...
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adult, Aged, Aged, 80 and over, Carcinoma, Pancreatic Ductal, mortality, pathology, surgery, Female, Humans, Lymph Node Excision, Lymphatic Metastasis, Male, Middle Aged, Neoplasm Staging, Pancreas, pathology, Pancreatic Neoplasms, mortality, pathology, surgery, Pancreaticoduodenectomy, adverse effects, Prognosis, Prospective Studies, Sentinel Lymph Node, pathology, Survival Analysis, Sweden, Tertiary Care Centers
Ämneskategorier Cancer och onkologi

Sammanfattning

An investigation of patients with pancreatic carcinoma aims to identify those who will benefit from surgery. Physical examination, radiology and laboratory findings are helpful. Most prognostic markers, such as lymph node status, micro metastasis and tumour differentiation, are not preoperatively accessible. Metastatic disease in lymph node 8a (Ln8a) in patients operated for pancreatic carcinoma has been reported to be a predictor of shorter overall survival (OS). This lymph node can be assessed preoperatively through resection (possibly even with laparoscopy) and subsequent histopathology. The value of the procedure is disputed. The aim of this study is to investigate whether metastatic disease in Ln8a is a predictor of decreased OS.In patients with suspected pancreatic or periampullary carcinoma, who were operated with pancreatoduodenectomy (PD), Ln8a was separately resected and analysed with standard and immuno-histochemical methods. Patients with or without metastasis in Ln8a were compared regarding OS.Between 2008 and 2011, 122 consecutive patients were eligible and 87 were resected and had LN8a analysed separately. Sixteen patients were Ln8a + and 71 were Ln8a-. Patients with Ln8a + had a significantly reduced median OS as compared to patients with Ln8a- (0.74 (95% CI 0.26-1.26) versus 5.91 years (95% CI 2.91-), p < .001).Ln8a + was associated with a marked reduction of OS, indicating a possible role in the future preoperative workup in patients with a suspicion of pancreatic cancer.

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