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Neural gain control measured through cortical gamma oscillations is associated with sensory sensitivity.

Artikel i vetenskaplig tidskrift
Författare Elena V Orekhova
Tatiana A Stroganova
Justin F. Schneiderman
Sebastian Lundström
Bushra Riaz
Darko Sarovic
Olga V Sysoeva
Georg Brant
Christopher Gillberg
Nouchine Hadjikhani
Publicerad i Human brain mapping
Volym 40
Nummer/häfte 5
Sidor 1583-1593
ISSN 1097-0193
Publiceringsår 2019
Publicerad vid Institutionen för neurovetenskap och fysiologi
Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap
Gillbergcentrum
Sidor 1583-1593
Språk en
Länkar dx.doi.org/10.1002/hbm.24469
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord autism spectrum disorders; gamma oscillations; magneto-encephalography; response gain control; sensory sensitivity; visual motion
Ämneskategorier Barn- och ungdomspsykiatri

Sammanfattning

Gamma oscillations facilitate information processing by shaping the excitatory input/output of neuronal populations. Recent studies in humans and nonhuman primates have shown that strong excitatory drive to the visual cortex leads to suppression of induced gamma oscillations, which may reflect inhibitory-based gain control of network excitation. The efficiency of the gain control measured through gamma oscillations may in turn affect sensory sensitivity in everyday life. To test this prediction, we assessed the link between self-reported sensitivity and changes in magneto-encephalographic gamma oscillations as a function of motion velocity of high-contrast visual gratings. The induced gamma oscillations increased in frequency and decreased in power with increasing stimulation intensity. As expected, weaker suppression of the gamma response correlated with sensory hypersensitivity. Robustness of this result was confirmed by its replication in the two samples: neurotypical subjects and people with autism, who had generally elevated sensory sensitivity. We conclude that intensity-related suppression of gamma response is a promising biomarker of homeostatic control of the excitation-inhibition balance in the visual cortex.

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