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Sclerosis as a predictive factor for failure after bulbar urethroplasty: a prospective single-centre study.

Artikel i vetenskaplig tidskrift
Författare Teresa Ekerhult
Klas Lindqvist
Lars Grenabo
Christina Kåbjörn Gustafsson
Ralph Peeker
Publicerad i Scandinavian journal of urology
Volym 52
Nummer/häfte 4
Sidor 302-308
ISSN 2168-1813
Publiceringsår 2018
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för urologi
Institutionen för kliniska vetenskaper
Sidor 302-308
Språk en
Länkar dx.doi.org/10.1080/21681805.2018.15...
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämneskategorier Klinisk medicin

Sammanfattning

The aim of this study was to assess whether sclerosis in histology following bulbar urethroplasty is a predictive factor for failure of surgery.Resected stricture specimens from 45 patients undergoing open urethroplasty with excision and anastomosis were collected prospectively during 2011-2014. Histopathological characteristics, including fibrosis (grade I-III), inflammation and sclerosis, were evaluated using different routine staining. These specimens were compared to normal urethral resection specimens from patients undergoing sex-correction surgery. The uropathologist who conducted the analyses was blinded to the study design.The outcomes of the histological classifications were as follows: 19 patients had grade I fibrosis, of whom three had failures; 13 patients had grade II fibrosis, without any failures; and the most severe fibrosis, grade III, including sclerosis, was found in 13 patients (11 with sclerosis), with failure in eight. Sclerosis was a significant risk factor for restricture when comparing patients with sclerosis and those without sclerosis, and likewise when adjusting for age, inflammation and stricture length.Histological findings of sclerosis in the resected urethral stricture specimen indicate a significantly higher risk for restricture after urethroplasty surgery.

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