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European trends in epilepsy surgery.

Artikel i vetenskaplig tidskrift
Författare Maxime O Baud
Thomas Perneger
Attila Rácz
Max C Pensel
Christian Elger
Bertil Rydenhag
Kristina Malmgren
J. Helen Cross
Grainne McKenna
Martin Tisdall
Herm J Lamberink
Sylvain Rheims
Philippe Ryvlin
Jean Isnard
François Mauguière
Alexis Arzimanoglou
Serdar Akkol
Kaancan Deniz
Cigdem Ozkara
Morten Lossius
Ivan Rektor
Reetta Kälviäinen
Lotta-Maria Vanhatalo
Petia Dimova
Krassimir Minkin
Anke Maren Staack
Bernhard J Steinhoff
Adam Kalina
Pavel Krsek
Petr Marusic
Zsofia Jordan
Daniel Fabo
Evelien Carrette
Paul Boon
Saulius Rocka
Rūta Mameniškienė
Serge Vulliemoz
Francesca Pittau
Kees P J Braun
Margitta Seeck
Publicerad i Neurology
Volym 91
Nummer/häfte 2
Sidor e96-e106
ISSN 1526-632X
Publiceringsår 2018
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap
Sidor e96-e106
Språk en
Länkar dx.doi.org/10.1212/WNL.000000000000...
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämneskategorier Neurokirurgi

Sammanfattning

Resective surgery is effective in treating drug-resistant focal epilepsy, but it remains unclear whether improved diagnostics influence postsurgical outcomes. Here, we compared practice and outcomes over 2 periods 15 years apart.Sixteen European centers retrospectively identified 2 cohorts of children and adults who underwent epilepsy surgery in the period of 1997 to 1998 (n = 562) or 2012 to 2013 (n = 736). Data collected included patient (sex, age) and disease (duration, localization and diagnosis) characteristics, type of surgery, histopathology, Engel postsurgical outcome, and complications, as well as imaging and electrophysiologic tests performed for each case. Postsurgical outcome predictors were included in a multivariate logistic regression to assess the strength of date of surgery as an independent predictor.Over time, the number of operated cases per center increased from a median of 31 to 50 per 2-year period (p = 0.02). Mean disease duration at surgery decreased by 5.2 years (p < 0.001). Overall seizure freedom (Engel class 1) increased from 66.7% to 70.9% (adjusted p = 0.04), despite an increase in complex surgeries (extratemporal and/or MRI negative). Surgeries performed during the later period were 1.34 times (adjusted odds ratio; 95% confidence interval 1.02-1.77) more likely to yield a favorable outcome (Engel class I) than earlier surgeries, and improvement was more marked in extratemporal and MRI-negative temporal epilepsy. The rate of persistent neurologic complications remained stable (4.6%-5.3%, p = 0.7).Improvements in European epilepsy surgery over time are modest but significant, including higher surgical volume, shorter disease duration, and improved postsurgical seizure outcomes. Early referral for evaluation is required to continue on this encouraging trend.

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