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Association between cortical bone microstructure and statin use in older women.

Artikel i vetenskaplig tidskrift
Författare Berit Larsson
Daniel Sundh
Dan Mellström
Kristian F Axelsson
Anna G Nilsson
Mattias Lorentzon
Publicerad i The Journal of clinical endocrinology and metabolism
Volym 104
Nummer/häfte 2
Sidor 250-7
ISSN 1945-7197
Publiceringsår 2019
Publicerad vid Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition
Sidor 250-7
Språk en
Länkar dx.doi.org/10.1210/jc.2018-02054
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämneskategorier Endokrinologi

Sammanfattning

Treatment with statins has been associated with increased bone mineral density (BMD), but if this association depends on differences in cortical or trabecular volumetric bone microstructure is unknown.The aim of this study was to investigate if treatment with statins is associated with bone microstructure and geometry in older women.Older women were included in a population-based study of 3,028 women (mean age ± SD: 77.8 ± 1.6 years) from the greater Gothenburg area in Sweden. Information regarding medical history, medication and life-style factors was obtained from validated questionnaires.Bone geometry and microstructure were measured at the ultradistal and distal (14%) site of radius and tibia using high-resolution peripheral quantitative computed tomography (HR-pQCT; XtremeCT).The 803 women in the cohort who used statins had higher body weight, worse physical function and more frequently cardiovascular disease and diabetes than nonusers (p<0.05). Statin users had lower cortical porosity (radius 2.2± 1.9 vs. 2.5± 2.0%; tibia 5.2± 2.4 vs. 5.4± 2.5, p=0.01), higher cortical bone density (radius 1008 ± 39.1 vs. 1001 ± 38.4 mg/cm3; tibia 919 ± 42.6 vs. 914 ± 41.5, p<0.01), and greater cortical area (radius 60.5 ± 9.6 vs. 58.6 ± 9.7 mm2; tibia 150.0 ± 23.6 vs. 146.7 ± 23.8, p<0.01) than non-users, also after adjustment for a large number of confounders, including age, weight, smoking, other medications and prevalent diseases.Use of statins was associated with better cortical bone characteristics in older women.

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