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Diet-dependent gene expression highlights the importance of Cytochrome P450 in detoxification of algal secondary metabolites in a marine isopod

Artikel i vetenskaplig tidskrift
Författare Pierre De Wit
Keith Yamada
Marina Panova
Carl André
Kerstin Johannesson
Publicerad i Scientific Reports
Volym 8
Sidor 16824
ISSN 2045-2322
Publiceringsår 2018
Publicerad vid Institutionen för marina vetenskaper
Sidor 16824
Språk en
Länkar https://www.nature.com/articles/s41...
Ämnesord Idotea balthica, gene expression, detoxification, secondary metabolites
Ämneskategorier Cellbiologi, Genetik, Evolutionsbiologi, Bioinformatik och systembiologi

Sammanfattning

Isopods of the genus Idotea have an unusual ability to feed on algae containing high amounts of chemical defense molecules, such as species of the genera Fucus and Ulva. In this study, we compared gene expression patterns of Idotea balthica individuals fed with Fucus vesiculosus to individuals fed with Ulva lactuca. We generated the rst-ever transcriptome assembly for this species, and found 3,233 di erentially expressed genes across feeding regimes. However, only a handful of biological functions were enriched with regard to di erentially expressed genes, the most notable being “alkaloid metabolic process”. Within this category, we found eight di erentially expressed cytochrome P450 (CYP) unigenes, all of which had a higher expression in the U. lactuca diet treatment. A phylogenetic analysis showed that the di erentially expressed CYP genes are closely related to a CYP gene described from the hepatopancreas of the spiny lobster Panulirus argus, and we hypothesize that these transcripts are involved in metabolite detoxi cation. This is a rst step in the understanding of this algae-grazer interaction, and will form a basis for future work to characterize cytochrome P450 functioning in marine crustaceans.

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