Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

New alkylresorcinol metab… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

New alkylresorcinol metabolites in spot urine as biomarkers of whole grain wheat and rye intake in a Swedish middle-aged population

Artikel i vetenskaplig tidskrift
Författare R. Landberg
R. Wierzbicka
L. Shi
Sanna Nybacka
A. Kamal-Eldin
B. Hedblad
A. K. Lindroos
Anna Winkvist
Helene Berteus Forslund
Publicerad i European Journal of Clinical Nutrition
Volym 72
Nummer/häfte 10
Sidor 1439-1446
ISSN 0954-3007
Publiceringsår 2018
Publicerad vid Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition
Sidor 1439-1446
Språk en
Länkar dx.doi.org/10.1038/s41430-017-0079-...
Ämnesord randomized controlled-trial, cereal fiber intake, plasma, alkylresorcinols, postmenopausal women, insulin sensitivity, healthy, dietary, adults, reproducibility, consumption, Nutrition & Dietetics
Ämneskategorier Näringslära, Invärtesmedicin

Sammanfattning

Background/objectives Studies on the health effects of whole grains typically use self-reported intakes which are prone to large measurement errors. Dietary biomarkers that can provide an objective measure of intake are needed. New alkylresorcinol (AR) metabolites (3,5-dihydroxycinnamic acid (DHCA), 2-(3,5-dihydroxybenzamido)acetic acid (DHBA-glycine) and 5-(3,5-dihydroxyphenyl) pentanoic acid (DHPPTA)) in 24 h urine samples have been suggested as biomarkers for whole grain (WG) wheat and rye intake but remain to be evaluated in spot urine samples. Subjects/methods The reproducibility of the new AR metabolites (DHCA, DHBA-glycine and DHPPTA) was investigated in 4 repeated samples over a period of 2 wk in spot urine from 40 Swedish men and women enroled in the SCAPIS-study, after adjustment of creatinine Metabolite concentrations were correlated with total whole grain intake estimated during the same period. Results The medium-term reproducibility determined for DHCA, DHPPTA and DHBA-glycine varied from moderate to excellent (intra-class correlation coefficient = 0.35-0.67). Moreover, DHCA and DHBA-glycine were independently associated with self-reported total WG intake (beta = 0.18, P = 0.08 and beta = 0.18, P = 0.02, respectively) and all metabolites except for DHPPA were higher among women. Conclusions This study supports the idea of using AR metabolites in one or several spot urine samples as biomarkers of whole grain intake. These findings need to be confirmed in different populations.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?