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Combining gastric and ileal segments, does it overcome segment-related complications? An experimental study on rats.

Artikel i vetenskaplig tidskrift
Författare Berk Burgu
Mehmet İlker Gökce
Özgu Aydogdu
Evren Süer
Duygu Kankaya
Tarkan Soygür
Publicerad i Urological research
Volym 39
Nummer/häfte 1
Sidor 39-44
ISSN 1434-0879
Publiceringsår 2011
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi
Sidor 39-44
Språk en
Länkar dx.doi.org/10.1007/s00240-010-0283-...
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Animals, Electrolytes, blood, Female, Hyperplasia, pathology, Ileum, pathology, transplantation, Intestines, pathology, Metaplasia, pathology, Mucous Membrane, pathology, Postoperative Complications, pathology, Random Allocation, Rats, Rats, Sprague-Dawley, Stomach, pathology, transplantation, Urinary Bladder, pathology, surgery
Ämneskategorier Cancer och onkologi, Urologi och andrologi, Urologi och njurmedicin, Klinisk medicin

Sammanfattning

Bladder augmentation has revolutionized the care of children with neurogenic bladder but it is associated with certain short- and long-term complications. Using the combination of gastric and ileal segments to balance effects of these segments might be a solution for complications. A total of 39 female Spraque-Dawley rats randomly divided into four groups: ileocystoplasty (11), gastrocystoplasty (9), ileogastrocystoplasty (11) and control (8). Serum/urine electrolytes and pH values, and serum creatinine levels and urine mucus concentration were measured. Kruskal-Wallis non-parametric variance analysis was performed to compare the groups and p < 0.05 was accepted as significant. Metabolic alkalosis with significantly lower urine pH was observed in gastrocystoplasty group. Gastroileal group showed similar results with the ileal group in all parameters. No stone formation was detected in the sham and gastric cystoplasty groups. Metaplastic and hyperplastic changes were observed in all segments surrounding urothelium. In conclusion, combination of gastric and ileal segments does not significantly reduce the rate of metabolic impairments, stone and mucus formation. Besides it is not associated with significant improvement in histological outcome since urine is still in contact with the gastrointestinal mucosa.

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