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Attached stratified mucus separates bacteria from the epithelial cells in COPD lungs

Artikel i vetenskaplig tidskrift
Författare Dalia Fakih
Liisa Arike
Ana María Rodríguez-Piñeiro
Beatriz Martinez Abad
Elin Skansebo
S. Jackson
J. Root
D. Singh
Cristopher McCrae
C. M. Evans
A. Astrand
Anna Ermund
Gunnar C. Hansson
Publicerad i Jci Insight
Volym 3
Nummer/häfte 17
ISSN 2379-3708
Publiceringsår 2018
Publicerad vid Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi
Språk en
Länkar dx.doi.org/10.1172/jci.insight.1209...
Ämnesord obstructive pulmonary-disease, functional cftr channel, cystic-fibrosis, mucociliary clearance, intestinal mucus, mouse stomach, muc5ac mucin, protein, asthma, colon
Ämneskategorier Cellbiologi

Sammanfattning

The respiratory tract is normally kept essentially free of bacteria by cilia-mediated mucus transport, but in chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF), bacteria and mucus accumulates instead. To address the mechanisms behind the mucus accumulation, the proteome of bronchoalveolar lavages from COPD patients and mucus collected in an elastase-induced mouse model of COPD was analyzed, revealing similarities with each other and with the protein content in colonic mucus. Moreover, stratified laminated sheets of mucus were observed in airways from patients with CF and COPD and in elastase-exposed mice. On the other hand, the mucus accumulation in the elastase model was reduced in Muc5b-KO mice. While mucus plugs were removed from airways by washing with hypertonic saline in the elastase model, mucus remained adherent to epithelial cells. Bacteria were trapped on this mucus, whereas, in non-elastase-treated mice, bacteria were found on the epithelial cells. We propose that the adherence of mucus to epithelial cells observed in CF, COPD, and the elastase-induced mouse model of COPD separates bacteria from the surface cells and, thus, protects the respiratory epithelium.

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