Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Cytomegalovirus infection… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Cytomegalovirus infection management in solid organ transplant recipients across European centers in the time of molecular diagnostics: An ESGICH survey.

Artikel i vetenskaplig tidskrift
Författare David Navarro
Rafael San-Juan
Oriol Manuel
Estela Giménez
Mario Fernández-Ruiz
Hans H Hirsch
Paolo Antonio Grossi
José María Aguado
Vanda Friman
Inger Johansson
Publicerad i Transplant infectious disease : an official journal of the Transplantation Society
Volym 19
Nummer/häfte 6
ISSN 1399-3062
Publiceringsår 2017
Publicerad vid
Språk en
Länkar dx.doi.org/10.1111/tid.12773
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Antibiotic Prophylaxis, methods, standards, statistics & numerical data, Antiviral Agents, standards, therapeutic use, Cross-Sectional Studies, Cytomegalovirus, genetics, isolation & purification, Cytomegalovirus Infections, diagnosis, pathology, therapy, virology, DNA, Viral, isolation & purification, Europe, Guideline Adherence, statistics & numerical data, Health Care Surveys, statistics & numerical data, Humans, Immunocompromised Host, Immunosuppression, adverse effects, methods, Organ Transplantation, adverse effects, Postoperative Complications, diagnosis, pathology, therapy, virology, Practice Guidelines as Topic, Practice Patterns, Physicians', standards, statistics & numerical data, Real-Time Polymerase Chain Reaction, statistics & numerical data, Transplant Recipients, statistics & numerical data, Transplants, pathology, virology, Viral Load, methods
Ämneskategorier Infektionsmedicin

Sammanfattning

Scant information is available about how transplant centers are managing their use of quantitative molecular testing (QNAT) assays for active cytomegalovirus (CMV) infection monitoring in solid organ transplant (SOT) recipients. The current study was aimed at gathering information on current practices in the management of CMV infection across European centers in the era of molecular testing assays.A questionnaire-based cross-sectional survey study was conducted by the European Study Group of Infections in Immunocompromised Hosts (ESGICH) of the Society of Clinical Microbiology and Infectious Diseases (ESCMID). The invitation and a weekly reminder with a personal link to an Internet service provider (https://es.surveymonkey.com/) was sent to transplant physicians, transplant infectious diseases specialists, and clinical virologists working at 340 European transplant centers.Of the 1181 specialists surveyed, a total of 173 responded (14.8%): 73 transplant physicians, 57 transplant infectious diseases specialists, and 43 virologists from 173 institutions located at 23 different countries. The majority of centers used QNAT assays for active CMV infection monitoring. Most centers preferred commercially available real-time polymerase chain reaction (RT-PCR) assays over laboratory-developed procedures for quantifying CMV DNA load in whole blood or plasma. Use of a wide variety of DNA extraction platforms and RT-PCR assays was reported. All programs used antiviral prophylaxis, preemptive therapy, or both, according to current guidelines. However, the centers used different criteria for starting preemptive antiviral treatment, for monitoring systemic CMV DNA load, and for requesting genotypic assays to detect emerging CMV-resistant variants.Significant variation in CMV infection management in SOT recipients still remains across European centers in the era of molecular testing. International multicenter studies are required to achieve commutability of CMV testing and antiviral management procedures.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?