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Soluble urokinase-type plasminogen activator receptor is associated with signs of periodontitis in adolescents

Artikel i vetenskaplig tidskrift
Författare P. D. Skottrup
Gunnar Dahlén
V. Baelum
R. Lopez
Publicerad i European Journal of Oral Sciences
Volym 126
Nummer/häfte 4
Sidor 292-299
ISSN 0909-8836
Publiceringsår 2018
Publicerad vid Institutionen för odontologi
Sidor 292-299
Språk en
Länkar dx.doi.org/10.1111/eos.12424
Ämnesord biomarker, diagnostics, inflammation, periodontopathogens, saliva, clinical attachment loss, dna-dna hybridization, serum antibody, general-population, disease, supar, epidemiology, technology, prevalence, microbiota, Dentistry, Oral Surgery & Medicine
Ämneskategorier Odontologi

Sammanfattning

Owing to its molecular stability in body fluids, soluble urokinase-type plasminogen activator receptor (suPAR) is used as a biomarker for the level of systemic inflammation. This study compares the suPAR levels in serum with those in the saliva of adolescents and evaluates their association with the periodontal conditions. Adolescents identified as screen positive (n = 87) or screen negative (n = 73) for periodontitis had saliva and serum samples taken, along with subgingival plaque samples. The concentrations of suPAR were determined in saliva and serum, and 18 microbial species and the immunoglobulin response to them was evaluated. Factor analyses were used to reduce the number of variables within each of the domains of clinical, microbiological, and immunological findings. The median salivary suPAR concentration was 13.18 [(interquartile range (IQR): 6.20-23.36] g l(-1) and was not associated with the serum suPAR levels (median 2.05; IQR: 1.62-2.46 g l(-1)). Linear regression analysis showed that the log(10)(salivary suPAR concentration) was statistically significantly positively associated with the clinical phenotype Periodontitis Extent' ( = 0.28; 95% CI: 0.16-0.39) along with Putative periodontopathogens' ( = 0.65; 95% CI: 0.51-0.79). The study represents the first determination of salivary suPAR concentration in a larger well-defined adolescent population. Our results suggest the potential for clinical use of suPAR in saliva as an inflammatory risk indicator/biomarker of periodontitis.

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