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A mechanistic linkage between oral lichen planus and autoimmune thyroid disease.

Artikel i vetenskaplig tidskrift
Författare Jairo Robledo-Sierra
Kerstin Landin-Wilhelmsen
Helena Filipsson Nyström
Robert Eggertsen
Lena Larsson
Amal Dafar
G Warfvinge
Ulf Mattsson
Mats Jontell
Publicerad i Oral diseases
Volym 24
Nummer/häfte 6
Sidor 1001-1011
ISSN 1601-0825
Publiceringsår 2018
Publicerad vid Institutionen för odontologi
Institutionen för odontologi, sektion 1
Institutionen för odontologi, sektion 2
Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa
Institutionen för medicin
Sidor 1001-1011
Språk en
Länkar dx.doi.org/10.1111/odi.12850
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämneskategorier Klinisk medicin, Endokrinologi och diabetes

Sammanfattning

To determine the levels of antithyroid antibodies and thyroid hormones in the sera of patients with oral lichen planus (OLP), and to quantify the expression of thyroid proteins in OLP lesions.Venous blood samples were drawn from 110 patients with OLP who had no history of thyroid disease or levothyroxine supplementation (OLP+/LT4 -). A random population sample of 657 healthy subjects was used as the control group. Two additional groups were used as comparators. Immunohistochemical and qPCR analyses were performed on tissue specimens collected from the patients with OLP and thyroid disease and healthy subjects.No association was found between the presence of antithyroid antibodies and OLP. More patients in the OLP+/LT4 - group showed high levels of thyroid-stimulating hormone and low levels of free thyroxine than were seen in the control group. Thyroid-stimulating hormone receptor was more highly expressed in the OLP lesions of patients with thyroid disease than in the healthy oral mucosa.A significant number of patients with OLP who are not previously diagnosed with thyroid disease have thyroid parameters that are compatible with hypothyroidism. The expression of thyroid-stimulating hormone receptor in OLP lesions suggests that mechanisms related to autoimmune thyroid disease are involved in the aetiology of OLP.

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