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A stage-dependent link between metabolic syndrome components and incident prostate cancer

Forskningsöversiktsartikel
Författare Jan Hammarsten
Jan-Erik Damber
Mohammad-Ali Haghsheno
Dan Mellström
Ralph Peeker
Publicerad i Nature Reviews Urology
Volym 15
Nummer/häfte 5
Sidor 321-333
ISSN 1759-4812
Publiceringsår 2018
Publicerad vid Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa
Institutionen för kliniska vetenskaper, Avdelningen för urologi
Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition
Sidor 321-333
Språk en
Länkar dx.doi.org/10.1038/nrurol.2018.8
Ämnesord antidiabetic agent, insulin, sex hormone, cancer incidence, cancer research, cancer staging, diabetes mellitus, disease association, human, insulin blood level, lethality, medical care, metabolic syndrome X, priority journal, prostate cancer, Review
Ämneskategorier Cancer och onkologi, Urologi och andrologi

Sammanfattning

Metabolic syndrome is associated with increased cancer risk and progression at almost all sites, including the prostate in high-stage prostate cancer. However, several reports have described an inverse relationship between metabolic syndrome and its components and low-stage incident prostate cancer. Such anomalies in cancer research hamper efforts to fight cancer. Evidence suggests that metabolic syndrome and its components have two distinct effects in prostate cancer, concealing prostate cancer in low-stage disease and promoting progression to high-stage incident, nonlocalized, and lethal prostate cancer. The concealment of prostate cancer by metabolic syndrome and its components might be related to bias mechanisms that reduce PSA level and lead to a delayed diagnosis of low-stage prostate cancer, meaning that fewer men with metabolic syndrome are diagnosed with low-stage disease. The inverse link between metabolic syndrome and its components and low-stage incident prostate cancer might simply be the result of such bias and the shortcomings of the diagnostic procedure rather than being related to prostate cancer biology itself. The evidence summarized here supports the hypothesis that the link between metabolic syndrome and its components and incident prostate cancer is a two-way and stage-dependent one, a theory that requires further research. © 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.

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