Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Subversion of innate immu… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Subversion of innate immune responses by Francisella involves the disruption of TRAF3 and TRAF6 signalling complexes.

Artikel i vetenskaplig tidskrift
Författare Daniela Putzova
Swarupa Panda
Anetta Härtlova
Jiří Stulík
Nelson O Gekara
Publicerad i Cellular microbiology
Volym 19
Nummer/häfte 11
ISSN 1462-5822
Publiceringsår 2017
Publicerad vid
Språk en
Länkar dx.doi.org/10.1111/cmi.12769
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adaptor Proteins, Signal Transducing, genetics, Adaptor Proteins, Vesicular Transport, genetics, Animals, Francisella tularensis, immunology, pathogenicity, Immune Evasion, immunology, Immunity, Innate, immunology, Mice, Mice, Inbred C57BL, Mice, Knockout, Myeloid Differentiation Factor 88, genetics, Receptors, Pattern Recognition, antagonists & inhibitors, TNF Receptor-Associated Factor 3, metabolism, TNF Receptor-Associated Factor 6, metabolism, Tularemia, immunology, microbiology, pathology, Type VI Secretion Systems, metabolism, Ubiquitination, immunology
Ämneskategorier Immunologi, Mikrobiologi och immunologi

Sammanfattning

The success of pathogens depends on their ability to circumvent immune defences. Francisella tularensis is one of the most infectious bacteria known. The remarkable virulence of Francisella is believed to be due to its capacity to evade or subvert the immune system, but how remains obscure. Here, we show that Francisella triggers but concomitantly inhibits the Toll-like receptor, RIG-I-like receptor, and cytoplasmic DNA pathways. Francisella subverts these pathways at least in part by inhibiting K63-linked polyubiquitination and assembly of TRAF6 and TRAF3 complexes that control the transcriptional responses of pattern recognition receptors. We show that this mode of inhibition requires a functional type VI secretion system and/or the presence of live bacteria in the cytoplasm. The ability of Francisella to enter the cytosol while simultaneously inhibiting multiple pattern recognition receptor pathways may account for the notable capacity of this bacterium to invade and proliferate in the host without evoking a self-limiting innate immune response.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?