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Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance.

Artikel i vetenskaplig tidskrift
Författare Stephan P Rosshart
Brian G Vassallo
Davide Angeletti
Diane S Hutchinson
Andrew P Morgan
Kazuyo Takeda
Heather D Hickman
John A McCulloch
Jonathan H Badger
Nadim J Ajami
Giorgio Trinchieri
Fernando Pardo-Manuel de Villena
Jonathan W Yewdell
Barbara Rehermann
Publicerad i Cell
Volym 171
Nummer/häfte 5
Sidor 1015-1028.e13
ISSN 1097-4172
Publiceringsår 2017
Publicerad vid
Sidor 1015-1028.e13
Språk en
Länkar dx.doi.org/10.1016/j.cell.2017.09.0...
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Animals, Animals, Laboratory, Animals, Wild, Carcinogenesis, immunology, Disease Resistance, Female, Gastrointestinal Microbiome, Male, Maryland, Mice, classification, immunology, microbiology, Mice, Inbred C57BL, Peromyscus, Virus Diseases, immunology
Ämneskategorier Immunologi inom det medicinska området, Mikrobiologi inom det medicinska området

Sammanfattning

Laboratory mice, while paramount for understanding basic biological phenomena, are limited in modeling complex diseases of humans and other free-living mammals. Because the microbiome is a major factor in mammalian physiology, we aimed to identify a naturally evolved reference microbiome to better recapitulate physiological phenomena relevant in the natural world outside the laboratory. Among 21 distinct mouse populations worldwide, we identified a closely related wild relative to standard laboratory mouse strains. Its bacterial gut microbiome differed significantly from its laboratory mouse counterpart and was transferred to and maintained in laboratory mice over several generations. Laboratory mice reconstituted with natural microbiota exhibited reduced inflammation and increased survival following influenza virus infection and improved resistance against mutagen/inflammation-induced colorectal tumorigenesis. By demonstrating the host fitness-promoting traits of natural microbiota, our findings should enable the discovery of protective mechanisms relevant in the natural world and improve the modeling of complex diseases of free-living mammals. VIDEO ABSTRACT.

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