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Randomised study of children with obesity showed that whole body vibration reduced sclerostin.

Artikel i vetenskaplig tidskrift
Författare Bojan Tubić
Rickard Zeijlon
Göran Wennergren
Barbara Obermayer-Pietsch
Staffan Mårild
Jovanna Dahlgren
Per Magnusson
Diana Swolin-Eide
Publicerad i Acta paediatrica (Oslo, Norway : 1992)
Volym 108
Nummer/häfte 3
Sidor 502-513
ISSN 1651-2227
Publiceringsår 2019
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för öron-, näs- och halssjukdomar
Institutionen för kliniska vetenskaper, Avdelningen för pediatrik
Sidor 502-513
Språk en
Länkar dx.doi.org/10.1111/apa.14531
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämneskategorier Pediatrik

Sammanfattning

New strategies are required to increase physical activity and improve metabolic profiles in children with obesity. We studied the effect of whole body vibration (WBV) on children with obesity on biochemical markers of energy and bone metabolism, anthropometric measurements, muscle parameters and calcaneal bone mineral density (BMD).This was a randomised, prospective, controlled study of 30 children with a median age of 13 years (range 7-17) at Queen Silvia Children's Hospital, Gothenburg, Sweden, from 2013-2015. The target for the intervention group was to perform WBV three times a week for 12 weeks and the study parameters were assessed at baseline and 12 weeks.The 16 in the WBV group achieved 51% of the planned activity, mainly at home, and were compared with 14 controls. Sclerostin, bone-specific alkaline phosphatase and carboxy-terminal collagen crosslinks decreased in the WBV group (p<0.05) and balance improved (p<0.006), but osteocalcin and insulin remained unchanged. Anthropometric data, muscle strength and calcaneal BMD did not differ between the groups.WBV did not affect most of the clinical parameters in children with obesity, but the reduction of sclerostin implies that it had direct effects on osteocytes, which are key players in bone mechanotransduction. This article is protected by copyright. All rights reserved.

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