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Components in Lentinus edodes mushroom with anti-biofilm activity directed against bacteria involved in caries and gingivitis

Artikel i vetenskaplig tidskrift
Författare A. Papetti
C. Signoretto
D. A. Spratt
J. Pratten
Peter Lingström
E. Zaura
I. Ofek
M. Wilson
C. Pruzzo
G. Gazzani
Publicerad i Food & Function
Volym 9
Nummer/häfte 6
Sidor 3489-3499
ISSN 2042-6496
Publiceringsår 2018
Publicerad vid Institutionen för odontologi
Sidor 3489-3499
Språk en
Länkar dx.doi.org/10.1039/c7fo01727h
Ämnesord edible mushroom, organic-acids, antibacterial activity, antimicrobial, activity, antioxidant activities, liquid-chromatography, quantitative-analyses, cultivated mushrooms, pathogenic bacteria, antitumor-activity, Biochemistry & Molecular Biology, Food Science & Technology
Ämneskategorier Odontologi

Sammanfattning

The present study investigated the compounds present in the low molecular mass fraction of Lentinus edodes mushroom (shiitake) extract and their anti-virulence activity against oral pathogens (reference and clinical Streptococcus mutans, Actinomyces naeslundii, and Prevotella intermedia strains). Oxalic, succinic, and quinic acids, and adenine, inosine, and uridine were identified by HPLC-DAD-ESI-MS/MS. Their anti-biofilm production and preformed biofilm disaggregation activities were studied using commercial standard compounds at different concentrations. As regards S. mutans, the highest activity was shown by adenine at 5 mg mL(-1) both in the biofilm inhibition (BI 50%) and biofilm disaggregation tests (BD 20%). Considering A. naeslundii, BI values close to 80% were registered for oxalic acid at 1 mg mL(-1) and 2 mg mL(-1) and BD 50% for quinic acid at 3 mg mL(-1). A weaker activity was found against P. intermedia. Furthermore, different mixtures of the commercial standards were tested showing that the activity of a compound can be strongly and sometimes negatively affected by the presence of the other compounds.

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