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Seroprevalence of Zika virus and Rubella virus IgG among blood donors in Rwanda and in Sweden

Artikel i vetenskaplig tidskrift
Författare Eric Seruyange
J. B. Gahutu
C. M. Muvunyi
S. Katare
V. Ndahindwa
H. Sibomana
J. Nyamusore
F. Rutagarama
Charles Hannoun
Helene Norder
Tomas Bergström
Publicerad i Journal of Medical Virology
Volym 90
Nummer/häfte 8
Sidor 1290-1296
ISSN 0146-6615
Publiceringsår 2018
Publicerad vid Institutionen för biomedicin, avdelningen för infektionssjukdomar
Sidor 1290-1296
Språk en
Länkar doi.org/10.1002/jmv.25198
Ämnesord ELISA, Rubella virus, Rwanda, seroprevalence, Zika virus, sexual transmission, french-polynesia, pregnant-women, coverage, dengue, Virology, SER A, 1970, Bulletin of the World Health Organization, V43, P539
Ämneskategorier Infektionsmedicin

Sammanfattning

Seroprevalence studies provide information on the susceptibility to infection of certain populations, including women of childbearing age. Such data from Central Africa are scarce regarding two viruses that cause congenital infections: Zika virus (ZIKV), an emerging mosquito-borne infection, and Rubella virus (RuV), a vaccine-preventable infection. We report on the seroprevalence of both ZIKV and RuV from Rwanda, a country without any known cases of ZIKV, but bordering Uganda where this virus was isolated in 1947. Anti-ZIKV-specific and anti-RuV-specific immunoglobulin G (IgG) antibodies were analyzed by enzyme-linked immunosorbent assay (ELISA) in serum samples from 874 Rwandan and 215 Swedish blood donors. Samples positive for IgG antibodies against ZIKV were examined for viral RNA using real-time reverse transcription polymerase chain reaction (RT-qPCR). The seroprevalence of ZIKV IgG in Rwanda was 1.4% (12/874), of which the predominance of positive findings came from the Southeastern region. All anti-ZIKV IgG-positive samples were PCR-negative. Among 297 female blood donors of childbearing age, 295 (99.3%) were seronegative and thus susceptible to ZIKV. All Swedish blood donors were IgG-negative to ZIKV. In contrast, blood donors from both countries showed high seroprevalence of IgG to RuV: 91.2% for Rwandan and 92.1% for Swedish donors. Only 10.5% (31/294) of female donors of childbearing age from Rwanda were seronegative for RuV. In Rwanda, seroprevalence for ZIKV IgG antibodies was low, but high for RuV. Hence, women of childbearing age were susceptible to ZIKV. These data may be of value for decision-making regarding prophylactic measures.

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