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Brown adipose tissue in young adults who were born preterm or small for gestational age

Artikel i vetenskaplig tidskrift
Författare Anna Kistner
H. Ryden
B. Anderstam
Ann Hellström
M. Skorpil
Publicerad i Journal of Pediatric Endocrinology & Metabolism
Volym 31
Nummer/häfte 6
Sidor 641-647
ISSN 0334-018X
Publiceringsår 2018
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap
Sidor 641-647
Språk en
Länkar https://doi.org/10.1515/jpem-2017-0...
Ämnesord adults and pediatrics, endocrine disorders, magnetic resonance imaging, positron-emission-tomography, water-fat separation, blood-pressure, cold-exposure, humans, children, growth, mri, appropriate, spectrum, Endocrinology & Metabolism, Pediatrics
Ämneskategorier Pediatrik, Endokrinologi och diabetes

Sammanfattning

Background: Brown adipose tissue (BAT) is present and functions to dissipate energy as heat in young adults and can be assessed using magnetic resonance imaging (MRI) to estimate the voxel fat fraction, i.e. proton density fat fraction (PDFF). It is hypothesized that subjects born preterm or small for gestational age (SGA) may exhibit disrupted BAT formation coupled to metabolic factors. Our purpose was to assess the presence of BAT in young adults born extremely preterm or SGA in comparison with controls. Methods: We studied 30 healthy subjects (median age, 21 years): 10 born extremely preterm, 10 full term but SGA and 10 full term with a normal birth weight (controls). We utilized an MRI technique combining multiple scans to enable smaller echo spacing and an advanced fat-water separation method applying graph cuts to estimate B-0 inhomogeneity. We measured supraclavicular/cervical PDFF, R2*, fat volume, insulin-like growth factor 1, glucagon, thyroid stimulating hormone and the BAT-associated hormones fibroblast growth factor 21 and irisin. Results: The groups did not significantly differ in supra-clavicular/ cervical PDFF, R2*, fat volume or hormone levels. The mean supraclavicular/cervical PDFF was equivalent between the groups (range 75-77%). Conclusions: Young adults born extremely preterm or SGA show BAT development similar to those born full term at a normal birth weight. Thus, the increased risk of cardiovascular and metabolic disorders in these groups is not due to the absence of BAT, although our results do not exclude possible BAT involvement in this scenario. Larger studies are needed to understand these relationships.

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