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Structural basis for Acinetobacter baumannii biofilm formation

Artikel i vetenskaplig tidskrift
Författare N. Pakharukova
M. Tuittila
S. Paavilainen
H. Malmi
O. Parilova
Susann Teneberg
S. D. Knight
A. V. Zavialov
Publicerad i Proceedings of the National Academy of Sciences of the United States of America
Volym 115
Nummer/häfte 21
Sidor 5558-5563
ISSN 0027-8424
Publiceringsår 2018
Publicerad vid Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi
Sidor 5558-5563
Språk en
Länkar https://doi.org/10.1073/pnas.180096...
Ämnesord archaic pili, chaperone-usher pathway, bacterial adhesion, biofilm, Acinetobacter baumannii, drives fiber formation, pre-assembly complex, escherichia-coli, pilus, biogenesis, yersinia-pestis, psa fimbriae, adhesin, fimh, system, crystallization, Science & Technology
Ämneskategorier Medicinska grundvetenskaper

Sammanfattning

Acinetobacter baumannii-a leading cause of nosocomial infections-has a remarkable capacity to persist in hospital environments and medical devices due to its ability to form biofilms. Biofilm formation is mediated by Csu pili, assembled via the "archaic" chaperone-usher pathway. The X-ray structure of the CsuC-CsuE chaperone-adhesin preassembly complex reveals the basis for bacterial attachment to abiotic surfaces. CsuE exposes three hydrophobic finger-like loops at the tip of the pilus. Decreasing the hydrophobicity of these abolishes bacterial attachment, suggesting that archaic pili use tip-fingers to detect and bind to hydrophobic cavities in substrates. Antitip antibody completely blocks biofilm formation, presenting a means to prevent the spread of the pathogen. The use of hydrophilic materials instead of hydrophobic plastics in medical devices may represent another simple and cheap solution to reduce pathogen spread. Phylogenetic analysis suggests that the tip-fingers binding mechanism is shared by all archaic pili carrying two-domain adhesins. The use of flexible fingers instead of classical receptor-binding cavities is presumably more advantageous for attachment to structurally variable substrates, such as abiotic surfaces.

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