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Perioperative and postoperative quality of life in glioma patients - A longitudinal cohort study.

Artikel i vetenskaplig tidskrift
Författare Christina Drewes
Lisa Millgård Sagberg
Asgeir Store Jakola
Ole Solheim
Publicerad i World neurosurgery
Volym 117
Sidor e465-e474
ISSN 1878-8769
Publiceringsår 2018
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap
Sidor e465-e474
Språk en
Länkar dx.doi.org/10.1016/j.wneu.2018.06.0...
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämneskategorier Cancer och onkologi, Neurokirurgi

Sammanfattning

Few studies assess patient-reported quality of life (QoL) in glioma patients undergoing surgery, and even fewer provide longitudinal data. Accordingly, there is little knowledge about the changes of QoL over time in glioma patients. We sought to explore peri- and postoperative development of generic QoL during the first six months after primary glioma surgery.136 adult patients undergoing primary surgery for high-grade (HGG) or low-grade (LGG) glioma were prospectively included in this explorative, longitudinal study. Patient-reported QoL was measured with the generic tool EQ-5D 3L preoperatively and at 1 and 6 months after surgery.At group level, there was no difference in EQ-5D index values in patients with HGG compared to patients with LGG at baseline or at 1 month. At 6 months, EQ-5D index values in HGG patients had deteriorated significantly (p<0.001), but remained stable in LGG patients. Individual level QoL development was more diverse. American Society of Anesthesiology class ≥3, resection grades other than gross total resection (GTR) and HGG were identified as independent predictors for negative development of QoLbetween 1 and 6 months after surgery.At group level, development of generic QoL between baseline and 1 and 6 months postoperatively seems to follow the natural disease trajectories of LGG and HGG, with deterioration in HGG patients at 6 months. Individual development of QoL is heterogeneous. HGG, resection grades other than GTR and preoperative comorbidity are predictors of postoperative QoL-impairment.

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