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Elevated Urine Levels of Macrophage Migration Inhibitory Factor in Inflammatory Bladder Conditions: A Potential Biomarker for a Subgroup of Interstitial Cystitis/Bladder Pain Syndrome Patients

Artikel i vetenskaplig tidskrift
Författare P. L. Vera
D. M. Preston
R. M. Moldwin
D. R. Erickson
B. Mowlazadeh
F. Ma
D. E. Kouzoukas
K. L. Meyer-Siegler
Magnus Fall
Publicerad i Urology
Volym 116
Sidor 55-61
ISSN 0090-4295
Publiceringsår 2018
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för urologi
Sidor 55-61
Språk en
Länkar doi.org/10.1016/j.urology.2018.02.0...
Ämnesord syndrome/interstitial cystitis, prevalence, expression, diagnosis, ulcers, mif, Urology & Nephrology
Ämneskategorier Urologi och njurmedicin

Sammanfattning

OBJECTIVE To investigate whether urinary levels of macrophage migration inhibitory factor (MIF) are elevated in interstitial cystitis/bladder pain syndrome (IC/BPS) patients with Hunner lesions and also whether urine MIF is elevated in other forms of inflammatory cystitis. METHODS Urine samples were assayed for MIF by enzyme-linked immunosorbent assay. Urine samples from 3 female groups were examined: IC/BPS patients without (N = 55) and with Hunner lesions (N = 43), and non-IC/BPS patients (N = 100; control group; no history of IC/BPS; cancer or recent bacterial cystitis). Urine samples from 3 male groups were examined: patients with bacterial cystitis (N = 50), radiation cystitis (N = 18) and noncystitis patients (N = 119; control group; negative for bacterial cystitis). RESULTS Urine MIF (mean MIF pg/mL +/- standard error of the mean) was increased in female IC/BPS patients with Hunner lesions (2159 +/- 435.3) compared with IC/BPS patients without Hunner lesions (460 +/- 114.5) or non-IC/BPS patients (414 +/- 47.6). Receiver operating curve analyses showed that urine MIF levels discriminated between the 2 IC groups (area under the curve = 72%; confidence interval 61%-82%). Male patients with bacterial and radiation cystitis had elevated urine MIF levels (2839 +/- 757.1 and 4404 +/- 1548.1, respectively) compared with noncystitis patients (681 +/- 75.2). CONCLUSION Urine MIF is elevated in IC/BPS patients with Hunner lesions and also in patients with other bladder inflammatory and painful conditions. MIF may also serve as a noninvasive biomarker to select IC/BPS patients more accurately for endoscopic evaluation and possible anti-inflammatory treatment. (c) 2018 Elsevier Inc.

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