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APOE ε4 and the long arm of social inequity: estimated effects of socio-economic status and sex on the timing of dementia onset

Artikel i vetenskaplig tidskrift
Författare Caroline Hasselgren
Hans Ekbrand
Madeleine Mellqvist Fässberg
Anna Zettergren
Henrik Zetterberg
Kaj Blennow
Ingmar Skoog
Björn Halleröd
Publicerad i Ageing & Society
Volym 39
Nummer/häfte 9
Sidor 1951-1975
ISSN 0144-686X
Publiceringsår 2019
Publicerad vid Institutionen för sociologi och arbetsvetenskap
Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
Centrum för åldrande och hälsa (AgeCap)
Sidor 1951-1975
Språk en
Länkar https://doi.org/10.1017/S0144686X18...
Ämneskategorier Epidemiologi, Sociologi

Sammanfattning

It is well established that carriers of the apolipoprotein E (APOE) ε4 allele run a greater risk of developing Alzheimer's disease, the most common form of dementia and a strongly age-related condition known to disproportionally affect women. Low educational attainment also stands out as a prominent risk factor, and it has been suggested that occupational class plays a similar role in disease susceptibility. Not yet fully explored, however, is the question of whether socio-economic status (SES) could moderate the effect of APOE ε4. In the present paper, we address this issue. As substantial inequities in workforce participation and educational opportunities have existed between men and women in previous generations, we further examine whether SES-related moderations of the relationship between dementia and APOE ε4 are sex-specific. Our analyses are based on a sample of 580 individuals from the H70 Birth Cohort Study and the Prospective Population Study on Women in Gothenburg, Sweden. Data were analysed using Cox proportional hazards regression, and the results suggest that while high SES postpones dementia onset among male APOE ε4 carriers, this is not the case for women. These findings underscore the long-term impact of social inequity on health as well as the importance of considering potential interactions between social and genetic risk factors if we are to understand better the complex aetiology of dementia.

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