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Altered peripheral amino acid profile indicate a systemic impact of active celiac disease and a possible role of amino acids in disease pathogenesis

Artikel i vetenskaplig tidskrift
Författare Åsa Torinsson Naluai
Ladan Saadat Vafa
Audur Gudjonsdottir
H. Arnell
L. Browaldh
Staffan Nilsson
D. Agardh
Publicerad i Plos One
Volym 13
Nummer/häfte 3
ISSN 1932-6203
Publiceringsår 2018
Publicerad vid Institutionen för matematiska vetenskaper
Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi
Institutionen för kliniska vetenskaper
Språk en
Länkar https://doi.org/10.1371/journal.pon...
Ämnesord alanine, amino acid, glutamic acid, methionine, ornithine, proline, taurine, tryptophan, adolescent, amino acid analysis, amino acid blood level, Article, blood sampling, celiac disease, child, comparative study, controlled study, diet restriction, disease association, disease control, female, human, liquid chromatography-mass spectrometry, major clinical study, male, pathogenesis, tandem mass spectrometry
Ämneskategorier Immunologi inom det medicinska området

Sammanfattning

Background: We have previously performed a Genome Wide Association and linkage study that indicated a new disease triggering mechanism involving amino acid metabolism and nutrient sensing signaling pathways. Objective: The aim of this study was to investigate if plasma amino acid levels differed among children with celiac disease compared with disease controls. Materials and methods: Fasting plasma samples from 141 children with celiac disease and 129 non-celiac disease controls, were analyzed for amino acid levels by liquid chromatography-tandem mass spectrometry (LC/MS). A general linear model using age and experimental effects as covariates was used to compare amino acid levels between children with a diagnosis of celiac disease and controls. Results: Seven out of twenty-three analyzed amino acids were elevated in children with celiac disease compared with controls (tryptophan, taurine, glutamic acid, proline, ornithine, alanine and methionine). The significance of the individual amino acids do not survive multiple correction, however, multivariate analyses of the amino acid profile showed significantly altered amino acid levels in children with celiac disease overall and after correction for age, sex and experimental effects (p = 8.4 × 10-8). Conclusion: These findings support the idea that amino acids could influence systemic inflammation and play a possible role in disease pathogenesis. © 2018 Torinsson Naluai et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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