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Ventricular long-axis function is of major importance for long-term survival in patients with heart failure.

Artikel i vetenskaplig tidskrift
Författare Bente Grüner Sveälv
Eva Olofsson
Bert Andersson
Publicerad i Heart (British Cardiac Society)
Volym 94
Nummer/häfte 3
Sidor 284-9
ISSN 1468-201X
Publiceringsår 2008
Publicerad vid Wallenberglaboratoriet
Institutionen för medicin, avdelningen för molekylär och klinisk medicin
Sidor 284-9
Språk en
Länkar dx.doi.org/10.1136/hrt.2006.106294
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Atrial Fibrillation, diagnostic imaging, mortality, physiopathology, Echocardiography, methods, Epidemiologic Methods, Female, Heart Failure, diagnostic imaging, mortality, physiopathology, Humans, Male, Middle Aged, Stroke Volume, physiology, Systole, physiology, Ventricular Dysfunction, Left, complications, diagnostic imaging, mortality, physiopathology, Ventricular Dysfunction, Right, diagnostic imaging, mortality, physiopathology
Ämneskategorier Kardiologi

Sammanfattning

To assess the importance of ventricular systolic and diastolic long-axis (LAX) function in comparison with short-axis (SAX) function for prediction of long-term survival in patients with heart failure.Prospective epidemiological study.University and county hospital.Patients with idiopathic heart failure (n = 228), not older than 65 years, mean (SD) ejection fraction 44 (17)%, were investigated with echocardiography in the SAX and in the LAX basal parts of the right and left ventricle. Patients were followed up for 10 years with respect to total survival or heart transplantation.Left ventricular (LV) LAX systolic amplitude was a strong risk predictor of long-term survival (p<0.001). In a multivariate Cox proportional hazard analysis, adjusting for age, gender, heart rate, systolic blood pressure, and SAX fractional shortening, LAX systolic amplitude was the only independent predictor of outcome (hazard ratio = 0.89 (95% CI 0.80 to 0.98), p = 0.02). Survival curves for each quartile of LAX systolic amplitude differentiated between mild, moderate and severe dysfunction in relation to outcome (p<0.001). There was a significant correlation between SAX and LAX ventricular function only in the lower range of LAX systolic amplitude (<6.8 mm).LV LAX systolic amplitude independently predicted survival, after adjustment for clinical variables and LV SAX function. These data further emphasise the importance of the basal parts of the ventricles for ventricular function and thereby long-term outcome.

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