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Effects of androgens on the leptin system in immature male Atlantic salmon parr

Artikel i vetenskaplig tidskrift
Författare S. Trombley
A. Rocha
Björn Thrandur Björnsson
B. Borg
M. Schmitz
Publicerad i General and Comparative Endocrinology
Volym 257
Sidor 122-129
ISSN 0016-6480
Publiceringsår 2018
Publicerad vid Institutionen för biologi och miljövetenskap
Sidor 122-129
Språk en
Länkar dx.doi.org/10.1016/j.ygcen.2017.08....
Ämnesord Leptin, Leptin receptor, Testosterone, 11-ketotestosterone, Reproduction, Brain-pituitary-gonad axis, trout oncorhynchus-mykiss, early sexual-maturation, beta-subunit gene, adult-rat testis, rainbow-trout, in-vitro, receptor expression, genomic, characterization, tissue distribution, feedback-control, Endocrinology & Metabolism
Ämneskategorier Endokrinologi och diabetes

Sammanfattning

Leptin modulates all levels of the reproductive endocrine axis in mammals, and in turn, both leptin and the leptin receptor are regulated by sex steroids. The aim of this study was to investigate if sex steroids regulate the leptin system also in fish. Immature one-year old male Atlantic salmon parr were implanted with Silclear capsules that were either empty or filled with 11-ketoandrostenedione (11 KA) or testosterone (T) and the effects of 35-days treatment were investigated on measures of maturation, gene expression of leptin (lepa1, lepa2), leptin receptor (lepra1) and circulating plasma leptin. Both 11-KA and T stimulated the reproductive axis by increasing testes weight and up-regulated pituitary lh-beta mRNA levels and for T also fsh-beta. T up-regulated transcription levels of lepa1 and lepra1 in the pituitary, while 11-KA had no effect. Leptin receptor expression in the testis was unaltered by either androgen. T up-regulated lepa1 mRNA levels significantly also in the liver, but had no effect on lepa2, and 11 KA did not affect hepatic gene expression of either lepa1 or lepa2. Plasma leptin levels did not differ significantly between treatments. The results indicate that androgens regulate gene expression of leptin and the leptin receptor in different tissues in fish and that the effects of leptin might be tissue specific considering plasma levels remained unaltered. Overall, the results suggest a role for leptin in fish reproduction, where sex steroids are able to regulate components of the leptin system differentially in liver and important tissues of the reproductive axis. (C) 2017 Elsevier Inc. All rights reserved.

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