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PRO-C3: a new and more precise collagen marker for liver fibrosis in patients with chronic hepatitis C

Artikel i vetenskaplig tidskrift
Författare J. F. Hansen
M. J. Nielsen
Kristina Nyström
D. J. Leeming
Martin Lagging
Gunnar Norkrans
P. B. Christensen
M. Karsdal
Publicerad i Scandinavian Journal of Gastroenterology
Volym 53
Nummer/häfte 1
Sidor 83-87
ISSN 0036-5521
Publiceringsår 2018
Publicerad vid Institutionen för biomedicin, avdelningen för infektionssjukdomar
Sidor 83-87
Språk en
Länkar doi.org/10.1080/00365521.2017.13925...
Ämnesord Chronic hepatitis C, liver fibrosis, non-invasive methods, viral hepatitis, diagnostic tests, simple noninvasive index, infection, cirrhosis, predict, Gastroenterology & Hepatology, long er, 1988, biometrics, v44, p837
Ämneskategorier Infektionsmedicin

Sammanfattning

Objective: Detecting significant fibrosis and cirrhosis remains important in treatment and follow-up of patients with chronic hepatitis C Infection (CHC). The aim of this study was to assess the ability of PRO-C3 to identify significant fibrosis (Ishak score3) and cirrhosis (Ishak score5) both as a single test and as a part of algorithms.Materials and methods: PRO-C3 was assessed in baseline samples from the NORDynamIC trial. 270 patients were stratified into groups according to baseline biopsy. Baseline APRI, FIB-4 and GUCI scores were available for comparison in 232 patients.Results: PRO-C3 increased with Ishak scores (p=.001). Area under the curve (AUC) for significant fibrosis was 0.75 (95% CI 0.68-0.81) and 0.76 (95% CI 0.68-0.84) for cirrhosis. FIB-4, APRI and GUCI had similar AUCs. In a PRO-C3 algorithm including age, platelet count, body mass index (BMI) and international normalised ratio (INR), the diagnostic efficacy improved to 0.85 (CI 0.80-0.89) and 0.90 (IQR 0.84-0.96) for significant fibrosis and cirrhosis, respectively.Conclusions: In our study, PRO-C3 was an independent predictor of fibrosis stage, and may play an important role in managing CHC patients.

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