Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Disrupted Network Topolog… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Disrupted Network Topology in Patients with Stable and Progressive Mild Cognitive Impairment and Alzheimer's Disease

Artikel i vetenskaplig tidskrift
Författare Joana B. Pereira
Mite Mijalkov
Ehsan Kakaei
Patricia Mecocci
Bruno Vellas
Magda Tsolaki
Iwona Kłoszewska
Hilka Soininen
Christian Spenger
Simmon Lovestone
Andrew Simmons
Lars Olof Wahlund
Giovanni Volpe
Eric Westman
Publicerad i Cerebral Cortex
Volym 26
Sidor 3476-3493
ISSN 10473211
Publiceringsår 2016
Publicerad vid
Sidor 3476-3493
Språk en
Ämnesord closeness centrality, clustering, modularity, structural covariance networks, transitivity
Ämneskategorier Klinisk medicin

Sammanfattning

© 2016 Published by Oxford University Press. Recent findings suggest that Alzheimer's disease (AD) is a disconnection syndrome characterized by abnormalities in large-scale networks. However, the alterations that occur in network topology during the prodromal stages of AD, particularly in patients with stable mild cognitive impairment (MCI) and those that show a slow or faster progression to dementia, are still poorly understood. In this study, we used graph theory to assess the organization of structural MRI networks in stable MCI (sMCI) subjects, late MCI converters (lMCIc), early MCI converters (eMCIc), and AD patients from 2 large multicenter cohorts: ADNI and AddNeuroMed. Our findings showed an abnormal global network organization in all patient groups, as reflected by an increased path length, reduced transitivity, and increased modularity compared with controls. In addition, lMCIc, eMCIc, and AD patients showed a decreased path length and mean clustering compared with the sMCI group. At the local level, there were nodal clustering decreases mostly in AD patients, while the nodal closeness centrality detected abnormalities across all patient groups, showing overlapping changes in the hippocampi and amygdala and nonoverlapping changes in parietal, entorhinal, and orbitofrontal regions. These findings suggest that the prodromal and clinical stages of AD are associated with an abnormal network topology.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?