Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän

Aberrant cerebral network… - Göteborgs universitet Till startsida
Till innehåll Läs mer om hur kakor används på gu.se

Aberrant cerebral network topology and mild cognitive impairment in early Parkinson's disease

Artikel i vetenskaplig tidskrift
Författare Joana B. Pereira
Dag Aarsland
Cedric E. Ginestet
Alexander V. Lebedev
Lars Olof Wahlund
Andrew Simmons
Giovanni Volpe
Eric Westman
Publicerad i Human Brain Mapping
Volym 36
Sidor 2980-2995
ISSN 10659471
Publiceringsår 2015
Publicerad vid
Sidor 2980-2995
Språk en
Ämnesord characteristic path length, global efficiency, graph theory, hubs, structural co-variance networks
Ämneskategorier Klinisk medicin


© 2015 Wiley Periodicals, Inc. The aim of this study was to assess whether mild cognitive impairment (MCI) is associated with disruption in large-scale structural networks in newly diagnosed, drug-naïve patients with Parkinson's disease (PD). Graph theoretical analyses were applied to 3T MRI data from 123 PD patients and 56 controls from the Parkinson's progression markers initiative (PPMI). Thirty-three patients were classified as having Parkinson's disease with mild cognitive impairment (PD-MCI) using the Movement Disorders Society Task Force criteria, while the remaining 90 PD patients were classified as cognitively normal (PD-CN). Global measures (clustering coefficient, characteristic path length, global efficiency, small-worldness) and regional measures (regional clustering coefficient, regional efficiency, hubs) were assessed in the structural networks that were constructed based on cortical thickness and subcortical volume data. PD-MCI patients showed a marked reduction in the average correlation strength between cortical and subcortical regions compared with controls. These patients had a larger characteristic path length and reduced global efficiency in addition to a lower regional efficiency in frontal and parietal regions compared with PD-CN patients and controls. A reorganization of the highly connected regions in the network was observed in both groups of patients. This study shows that the earliest stages of cognitive decline in PD are associated with a disruption in the large-scale coordination of the brain network and with a decrease of the efficiency of parallel information processing. These changes are likely to signal further cognitive decline and provide support to the role of aberrant network topology in cognitive impairment in patients with early PD. Hum Brain Mapp 36:2980–2995, 2015. © 2015 Wiley Periodicals, Inc.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?