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Impact of killer-immunoglobulin-like receptor and human leukocyte antigen genotypes on the efficacy of immunotherapy in acute myeloid leukemia

Artikel i vetenskaplig tidskrift
Författare Elin Bernson
Alexander Hallner
Frida Ewald Sander
O. Wilsson
Olle Werlenius
Anna Rydström
Roberta Kiffin
Mats Brune
R. Foa
Johan Aurelius
Anna Martner
Kristoffer Hellstrand
Fredrik Bergh Thorén
Publicerad i Leukemia
Volym 31
Nummer/häfte 12
Sidor 2552-2559
ISSN 0887-6924
Publiceringsår 2017
Publicerad vid Sahlgrenska Cancer Center
Institutionen för medicin
Sidor 2552-2559
Språk en
Länkar doi.org/10.1038/leu.2017.151
Ämnesord mhc class-i, international expert panel, unlicensed nk cells, complex, class-i, inhibitory receptors, histamine dihydrochloride, cytomegalovirus-infection, self-tolerance, kir, molecules, Oncology, Hematology
Ämneskategorier Hematologi, Cancer och onkologi

Sammanfattning

Interactions between killer-immunoglobulin-like receptors (KIRs) and their HLA class I ligands are instrumental in natural killer (NK) cell regulation and protect normal tissue from NK cell attack. Human KIR haplotypes comprise genes encoding mainly inhibitory receptors (KIR A) or activating and inhibitory receptors (KIR B). A substantial fraction of humans lack ligands for inhibitory KIRs (iKIRs), that is, a 'missing ligand' genotype. KIR B/x and missing ligand genotypes may thus give rise to potentially autoreactive, unlicensed NK cells. Little is known regarding the impact of such genotypes in untransplanted acute myeloid leukemia (AML). For this study, NK cell phenotypes and KIR/HLA genotypes were determined in 81 AML patients who received immunotherapy with histamine dihydrochloride and low-dose IL-2 for relapse prevention (NCT01347996). We observed that presence of unlicensed NK cells impacted favorably on clinical outcome, in particular among patients harboring functional NK cells reflected by high expression of the natural cytotoxicity receptor (NCR) NKp46. Genotype analyses suggested that the clinical benefit of high NCR expression was restricted to patients with a missing ligand genotype and/or a KIR B/x genotype. These data imply that functional NK cells are significant anti-leukemic effector cells in patients with KIR/HLA genotypes that favor NK cell autoreactivity.

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