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Brain Capillary Ultrastructure in Idiopathic Normal Pressure Hydrocephalus: Relationship With Static and Pulsatile Intracranial Pressure

Artikel i vetenskaplig tidskrift
Författare V. A. Eidsvaag
Hans-Arne Hansson
K. Heuser
E. A. Nagelhus
P. K. Eide
Publicerad i Journal of Neuropathology and Experimental Neurology
Volym 76
Nummer/häfte 12
Sidor 1034-1045
ISSN 0022-3069
Publiceringsår 2017
Publicerad vid Institutionen för biomedicin
Sidor 1034-1045
Språk en
Länkar https://doi.org/10.1093/jnen/nlx091
Ämnesord Brain water turnover, Capillary basement membrane thickness, Human brain biopsy, Neurovascular, mouse cortical astrocytes, cerebral-blood-flow, alzheimers-disease, basement-membrane, aquaporin-4 polarization, pericyte degeneration, microvessels, drainage, features, arterioles, Neurosciences & Neurology, Pathology
Ämneskategorier Patologi, Neurovetenskaper

Sammanfattning

Idiopathic normal pressure hydrocephalus (iNPH) is a neurodegenerative disease of unknown cause. We investigated the morphology of capillaries in frontal cortex biopsies from iNPH patients and related the observations to overnight intracranial pressure (ICP) scores. A biopsy (0.9x10 mm) was taken from where the ICP sensor subsequently was inserted. Brain capillaries were investigated by electron microscopy of biopsies from 27 iNPH patients and 10 reference subjects, i.e. patients (not healthy individuals) without cerebrospinal fluid circulation disturbances, in whom normal brain tissue was removed as part of necessary neurosurgical treatment. Degenerating and degenerated pericyte processes were identified in 23/27 (85%) iNPH and 6/10 (60%) of reference specimens. Extensive disintegration of pericyte processes were recognized in 11/27 (41%) iNPH and 1/10 (10%) reference specimens. There were no differences in basement membrane (BM) thickness or pericyte coverage between iNPH and reference subjects. The pulsatile or static ICP scores did neither correlate with the BM thickness nor with pericyte coverage. We found increased prevalence of degenerating pericytes in iNPH while the BM thickness and pericyte coverage did not differ from the reference individuals. Observations in iNPH may to some extent be age-related since the iNPH patients were significantly older than the reference individuals.

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