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Impact of lung density on the lung dose estimation for radiotherapy of breast cancer

Artikel i vetenskaplig tidskrift
Författare Emma Hedin
Anna Bäck
Roumiana Chakarova
Publicerad i Physics and Imaging in Radiation Oncology
Volym 3
Sidor 5-10
ISSN 2405-6316
Publiceringsår 2017
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för radiofysik
Sidor 5-10
Språk en
Länkar https://doi.org/10.1016/j.phro.2017...
https://gup.ub.gu.se/file/207118
Ämnesord Breast cancer, Lung dose, DIBH, Acuros XB, Monte Carlo
Ämneskategorier Radiologi, Radiofysik

Sammanfattning

Background and purpose: To investigate the impact of the clinical implementation particle transport method on the lung dose evaluation for radiotherapy of breast cancer focusing on dosimetric effects of the lung density. Material and methods: Fourteen patients with left sided breast cancer having both deep inspiration breath hold (DIBH) and free breathing CT scans were studied. Lung density variations for 157 patients treated under DIBH were quantified and the cases with the lowest lung densities for breast and for loco regional treatment added to the study. Dose calculations were performed with the class-b type algorithm AAA and the deterministic algorithm Acuros XB. Monte Carlo method was utilized as reference. Differences in the dose distributions were evaluated by comparing DVH parameters. Results: Lung density variations between 0.08 and 0.3 g/cm3 and between 0.02 and 0.25 g/cm3 were found for loco-regional and tangential breast treatments under DIBH, respectively. Lung DVH parameters for patients with medium and high lung density obtained by the different algorithms agreed within 3%. Larger differences were observed for low lung density cases where the correction based algorithm underestimated V10Gy and overestimated V40Gy by up to 5%. The least affected parameter, V20Gy, deviated by less than 2% for all cases and densities. Conclusions: Dosimetric constrains for lung based on V20Gy required minimum changes due to implementation of the new algorithm regardless of breathing technique or type of treatment. Evaluation criteria utilizing V10Gy or V40Gy needed reconsideration, especially for treatments under DIBH involving low lung density.

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