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Long Noncoding RNA: Genome organization and mechanism of action

Kapitel i bok
Författare Vijay Suresh Akhade
D. Pal
Chandrasekhar Kanduri
Publicerad i Long Non Coding RNA Biology. M.R.S. Rao (red.)
Sidor 47-74
ISBN 978-981-10-5202-6
ISSN 0065-2598
Förlag Springer
Publiceringsår 2017
Publicerad vid Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi
Sidor 47-74
Språk en
Länkar doi.org/10.1007/978-981-10-5203-3_2
Ämnesord Chromatin, Epigenetics, Gene regulation, Genome organization, Long noncoding RNA
Ämneskategorier Cellbiologi

Sammanfattning

For the last four decades, we have known that noncoding RNAs maintain critical housekeeping functions such as transcription, RNA processing, and translation. However, in the late 1990s and early 2000s, the advent of high-throughput sequencing technologies and computational tools to analyze these large sequencing datasets facilitated the discovery of thousands of small and long noncoding RNAs (lncRNAs) and their functional role in diverse biological functions. For example, lncRNAs have been shown to regulate dosage compensation, genomic imprinting, pluripotency, cell differentiation and development, immune response, etc. Here we review how lncRNAs bring about such copious functions by employing diverse mechanisms such as translational inhibition, mRNA degradation, RNA decoys, facilitating recruitment of chromatin modifiers, regulation of protein activity, regulating the availability of miRNAs by sponging mechanism, etc. In addition, we provide a detailed account of different mechanisms as well as general principles by which lncRNAs organize functionally different nuclear sub-compartments and their impact on nuclear architecture. © 2017, Springer Nature Singapore Pte Ltd.

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