Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Effect of alcohol use dis… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Effect of alcohol use disorder on oxytocin peptide and receptor mRNA expression in human brain: A post-mortem case-control study

Artikel i vetenskaplig tidskrift
Författare M. R. Lee
M. L. Schwandt
V. Sankar
Petra Suchankova
H. Sun
L. Leggio
Publicerad i Psychoneuroendocrinology
Volym 85
Sidor 14-19
ISSN 0306-4530
Publiceringsår 2017
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi
Sidor 14-19
Språk en
Länkar doi.org/10.1016/j.psyneuen.2017.07....
Ämnesord Alcohol use disorder, Oxytocin, Oxytocin receptor, Post-mortem brain
Ämneskategorier Farmakologi

Sammanfattning

Animal and human evidence supports a role for oxytocin in alcohol-seeking behaviors. There is interest, therefore, in targeting the oxytocin pathway as a new pharmacologic approach to treat alcohol use disorder. To this end, it is important to understand the effect of alcohol use disorder on endogenous oxytocin in brain regions that are relevant for the initiation and maintenance of alcohol use disorder. We examined human post-mortem brain tissue from males with alcohol use disorder (n = 11) compared to nonalcohol dependent male controls (n = 16). We a priori targeted five brain regions that in rodent studies, are projection areas for oxytocin neurons: nucleus accumbens, amygdala, hippocampus, ventral tegmental area and prefrontal cortex. Fold change in mRNA levels of oxytocin peptide and receptor were measured in each of the brain regions studied. Fold change for oxytocin peptide mRNA was significantly elevated in the prefrontal cortex of subjects with alcohol use disorder compared to controls (uncorrected p = 0.0001; FDR-corrected p = 0.001). For the entire sample of 27 subjects, there was a significant positive correlation between the fold change in oxytocin peptide mRNA in the prefrontal cortex and both daily alcohol intake (r2 = 0.38; p = 0.002) and drinks per week (r2 = 0.24; p = 0.02). Results are discussed in light of the previous animal and human literature on changes in the endogenous oxytocin system as an effect of chronic alcohol exposure. © 2017

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?