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The normal trachea is cleaned by MUC5B mucin bundles from the submucosal glands coated with the MUC5AC mucin

Artikel i vetenskaplig tidskrift
Författare Anna Ermund
Lauren N Meiss
Ana María Rodríguez-Piñeiro
A. Bahr
Harriet E. Nilsson
Sergio Trillo-Muyo
C. Ridley
D. J. Thornton
J. J. Wine
H. Hebert
N. Klymiuk
Gunnar C. Hansson
Publicerad i Biochemical and Biophysical Research Communications - BBRC
Volym 492
Nummer/häfte 3
Sidor 331-337
ISSN 0006-291X
Publiceringsår 2017
Publicerad vid Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi
Sidor 331-337
Språk en
Länkar https://doi.org/10.1016/j.bbrc.2017...
Ämnesord Respiratory tract, Mucus, MUC5AC, Airway surface liquid, Lung, cystic-fibrosis, mucociliary transport, mucus, domain, airway, model, Biochemistry & Molecular Biology, Biophysics
Ämneskategorier Cellbiologi, Biofysik, Biokemi och molekylärbiologi

Sammanfattning

To understand the mucociliary clearance system, mucins were visualized by light, confocal and electron microscopy, and mucus was stained by Alcian blue and tracked by video microscopy on tracheal explants of newborn piglets. We observed long linear mucus bundles that appeared at the submucosal gland openings and were transported cephalically. The mucus bundles were shown by mass spectrometry and immunostaining to have a core made of MUC5B mucin and were coated with MUC5AC mucin produced by surface goblet cells. The transport speed of the bundles was slower than the airway surface liquid flow. We suggest that the goblet cell MUC5AC mucin anchors the mucus bundles and thus controls their transport. Normal clearance of the respiratory tree of pigs and humans, both rich in submucosal glands, is performed by thick and long mucus bundles. (C) 2017 The Authors. Published by Elsevier Inc.

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