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Tumour virology in the era of high-throughput genomics

Artikel i vetenskaplig tidskrift
Författare Ka-Wei Tang
Erik Larsson
Publicerad i Philosophical Transactions of the Royal Society B-Biological Sciences
Volym 372
Nummer/häfte 1732
ISSN 0962-8436
Publiceringsår 2017
Publicerad vid Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi
Institutionen för biomedicin, avdelningen för infektionssjukdomar
Språk en
Länkar dx.doi.org/10.1098/rstb.2016.0265
Ämnesord tumour virus, next-generation sequencing, virus integration, human cytomegalovirus-infection, human-papillomavirus, integration, sites, seronegative hepatitis, endometrial cancer, virus integration, chinese patients, breast-cancer, dna virus, rna-seq, oo ql, 1989, science, v244, p359, ang y, 1994, science, v266, p1865
Ämneskategorier Biologiska vetenskaper

Sammanfattning

With the advent of massively parallel sequencing, oncogenic viruses in tumours can now be detected in an unbiased and comprehensive manner. Additionally, new viruses or strains can be discovered based on sequence similarity with known viruses. Using this approach, the causative agent for Merkel cell carcinoma was identified. Subsequent studies using data from large collections of tumours have confirmed models built during decades of hypothesis-driven and low-throughput research, and a more detailed and comprehensive description of virus-tumour associations have emerged. Notably, large cohorts and high sequencing depth, in combination with newly developed bioinformatical techniques, have made it possible to rule out several suggested virus-tumour associations with a high degree of confidence. In this review we discuss possibilities, limitations and insights gained from using massively parallel sequencing to characterize tumours with viral content, with emphasis on detection of viral sequences and genomic integration events.

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