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| Författare |
Per Larsson Mona Lärstad Björn Bake Oscar Hammar Anna Bredberg Ann-Charlotte Almstrand Ekaterina Mirgorodskaya Anna-Carin Olin |
|---|---|
| Publicerad i | Clinical Physiology and Functional Imaging |
| Volym | 37 |
| Nummer/häfte | 5 |
| Sidor | 489-497 |
| ISSN | 1475-0961 |
| Publiceringsår | 2017 |
| Publicerad vid |
Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition |
| Sidor | 489-497 |
| Språk | en |
| Länkar |
doi.org/10.1111/cpf.12323 https://gup.ub.gu.se/file/207112 |
| Ämnesord | aerosol, airway opening, albumin, asthma, birch pollen, exhaled breath condensate, exhaled particles, PROTEINS SP-A, SURFACTANT PROTEINS, PULMONARY SURFACTANT, BRONCHOALVEOLAR LAVAGE, ALLERGIC PATIENTS, POLLEN, DISEASE, ALVEOLAR, ALBUMIN, LIQUID |
| Ämneskategorier | Miljömedicin och yrkesmedicin, Allergologi |
Exhaled breath contains suspended particles of respiratory tract lining fluid from the small airways. The particles are formed when closed airways open during inhalation. We have developed a method called Particles in Exhaled air (PExA((R))) to measure and sample these particles in the exhaled aerosol. Here, we use the PExA((R)) method to study the effects of birch pollen exposure on the small airways of individuals with asthma and birch pollen allergy. We hypothesized that birch pollen-induced inflammation could change the concentrations of surfactant protein A and albumin in the respiratory tract lining fluid of the small airways and influence the amount of exhaled particles. The amount of exhaled particles was reduced after birch pollen exposure in subjects with asthma and birch pollen allergy, but no significant effect on the concentrations of surfactant protein A and albumin in exhaled particles was found. The reduction in the number of exhaled particles may be due to inflammation in the small airways, which would reduce their diameter and potentially reduce the number of small airways that open and close during inhalation and exhalation.
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