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Radial artery intima-media thickness regresses after secondary prevention interventions in patients' post-acute coronary syndrome and is associated with cardiac and kidney biomarkers

Artikel i vetenskaplig tidskrift
Författare D. D. Adingupu
Helena Westergren
S. Dahgam
A. C. Jonsson-Rylander
Juuso I. Blomster
Per Albertsson
Elmir Omerovic
Sara Svedlund
Li-Ming Gan
Publicerad i Oncotarget
Volym 8
Nummer/häfte 32
Sidor 53419-53431
ISSN 1949-2553
Publiceringsår 2017
Publicerad vid Institutionen för medicin, avdelningen för molekylär och klinisk medicin
Sidor 53419-53431
Språk en
Länkar doi.org/10.18632/oncotarget.18511
Ämnesord atherosclerosis, cardiovascular, intima-media thickness, inflammation, ultrasound, INTENSITY STATIN THERAPY, C-REACTIVE PROTEIN, CARDIOVASCULAR RISK, CAROTID-ARTERY, DISEASE RISK, CYSTATIN-C, INTRAVASCULAR ULTRASOUND, ENDOTHELIAL GLYCOCALYX, MYOCARDIAL-INFARCTION, PLATELET INHIBITION
Ämneskategorier Kardiologi

Sammanfattning

Background: Radial artery intima-media thickness (rIMT) measured by ultra-high-resolution ultrasound is associated with increased cardiovascular risk and predicts outcomes. We performed non-invasive high-resolution ultrasound of the radial artery to investigate vascular changes in subjects presenting with acute coronary syndrome (ACS) and who had undergone percutaneous coronary intervention (PCI). Purpose: In the present work, we aimed to follow rIMT change over time post-acute coronary syndrome as a tool to monitor potential response to intensified medical therapy. Methods: We examined 256 subjects who underwent PCI due to ACS and healthy controls (n= 39) and we measured a number of biomarkers, which are known to be associated with cardiovascular disease. Images of radial artery were acquired bilaterally in the longitudinal view using a 50 MHz transducer (Vevo 2100 VisualSonics, Inc, Toronto, Ontario, Canada). Carotid IMT (cIMT) and rIMT were measured at <1 month after index PCI followed by a repeated measurement of rIMT at 4 months from the ACS in a sub-set (n= 117). Results: rIMT measured within 1 month post ACS was significantly higher than rIMT after 4 months from ACS, (p < 0.0001), mean +/- SD (rIMT right 0.35 +/- 0.08; rIMT left 0.37 +/- 0.08) vs. (rIMT right 0.29 +/- 0.08; rIMT left 0.31 +/- 0.09) respectively. There was no statistically significant change in cIMT. In healthy controls there were no changes in rIMT or cIMT overtime. High levels of CX3CL1 and myeloperoxidase measured within one month post ACS are associated with increase of rIMT, r=0.38 (p< 0.0001) and r=0.41 (p< 0.0001) respectively. Conclusions: rIMT seem to decrease systemically after ACS and is accompanied with corresponding biomarker change. The cause and clinical implications of the observed decrement in rIMT after ACS need further studies.

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