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The role of cholesterol metabolism and various steroid abnormalities in autism spectrum disorders: A hypothesis paper

Artikel i vetenskaplig tidskrift
Författare Christopher Gillberg
Elisabeth Fernell
Eva Kočovská
Helen Minnis
T. Bourgeron
Lucy Thompson
Clare Sarah Allely
Publicerad i Autism Research
Volym 10
Nummer/häfte 6
Sidor 1022-1044
ISSN 1939-3792
Publiceringsår 2017
Publicerad vid Gillbergcentrum
Sidor 1022-1044
Språk en
Länkar dx.doi.org/10.1002/aur.1777
https://gup.ub.gu.se/file/207019
Ämnesord autism, cholesterol, cortisol, estrogens, steroid hormones, testosterone, vitamin D, LEMLI-OPITZ-SYNDROME, CORTISOL CIRCADIAN-RHYTHMS, MALE BRAIN THEORY, VITAMIN-D, TUBEROUS SCLEROSIS, INTRANASAL OXYTOCIN, FUNCTIONING, CHILDREN, SYSTEMATIC REVIEWS, SALIVARY CORTISOL, PRISMA STATEMENT
Ämneskategorier Neurovetenskaper

Sammanfattning

Based on evidence from the relevant research literature, we present a hypothesis that there may be a link between cholesterol, vitamin D, and steroid hormones which subsequently impacts on the development of at least some of the autisms [Coleman & Gillberg]. Our hypothesis, driven by the peer reviewed literature, posits that there may be links between cholesterol metabolism, which we will refer to as steroid metabolism and findings of steroid abnormalities of various kinds (cortisol, testosterone, estrogens, progesterone, vitamin D) in autism spectrum disorder (ASD). Further research investigating these potential links is warranted to further our understanding of the biological mechanisms underlying ASD. Autism Res2017. (c) 2017 The Authors Autism Research published by Wiley Periodicals, Inc. on behalf of International Society for Autism Research. Autism Res 2017, 10: 1022-1044. (c) 2017 International Society for Autism Research, Wiley Periodicals, Inc.

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