Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Neural control of blood p… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Neural control of blood pressure in women: differences according to age

Artikel i vetenskaplig tidskrift
Författare A. B. Peinado
R. E. Harvey
E. C. Hart
N. Charkoudian
T. B. Curry
W. T. Nicholson
Gunnar B Wallin
M. J. Joyner
J. N. Barnes
Publicerad i Clinical Autonomic Research
Volym 27
Nummer/häfte 3
Sidor 157-165
ISSN 0959-9851
Publiceringsår 2017
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap
Sidor 157-165
Språk en
Länkar dx.doi.org/10.1007/s10286-017-0403-...
Ämnesord Aging, Baroreflex function, Menopause, Sympathetic nerve activity, SYMPATHETIC-NERVE ACTIVITY, LONG-TERM CONTROL, ARTERIAL-PRESSURE, BAROREFLEX SENSITIVITY, AUTONOMIC SUPPORT, HUMANS, 17-BETA-ESTRADIOL, MODULATION, ESTROGEN, BALANCE
Ämneskategorier Neurovetenskaper

Sammanfattning

Purpose The blood pressure "error signal'' represents the difference between an individual's mean diastolic blood pressure and the diastolic blood pressure at which 50% of cardiac cycles are associated with a muscle sympathetic nerve activity burst (the "T50''). In this study we evaluated whether T50 and the error signal related to the extent of change in blood pressure during autonomic blockade in young and older women, to study potential differences in sympathetic neural mechanisms regulating blood pressure before and after menopause. Methods We measured muscle sympathetic nerve activity and blood pressure in 12 premenopausal (25 +/- 1 years) and 12 postmenopausal women (61 +/- 2 years) before and during complete autonomic blockade with trimethaphan camsylate. Results At baseline, young women had a negative error signal (-8 +/- 1 versus 2 +/- 1 mmHg, p < 0.001; respectively) and lower muscle sympathetic nerve activity (15 +/- 1 versus 33 +/- 3 bursts/min, p < 0.001; respectively) than older women. The change in diastolic blood pressure after autonomic blockade was associated with baseline T50 in older women (r = -0.725, p = 0.008) but not in young women (r = -0.337, p = 0.29). Women with the most negative error signal had the lowest muscle sympathetic nerve activity in both groups (young: r = 0.886, p < 0.001; older: r = 0.870, p < 0.001). Conclusions Our results suggest that there are differences in baroreflex control of muscle sympathetic nerve activity between young and older women, using the T50 and error signal analysis. This approach provides further information on autonomic control of blood pressure in women.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?