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Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis

Artikel i vetenskaplig tidskrift
Författare Jason Brown
Christiana M. Cooper-Kuhn
Gerd Kempermann
Henriette Van Praag
Jürgen Winkler
Fred H. Gage
Hans-Georg Kuhn
Publicerad i European Journal of Neuroscience
Volym 17
Sidor 2042-2046
ISSN 0953816X
Publiceringsår 2003
Publicerad vid
Sidor 2042-2046
Språk en
Ämnesord Environmental stimulation, Exercise, Mouse, Proliferation
Ämneskategorier Neurovetenskap

Sammanfattning

Exposure to an enriched environment and physical activity, such as voluntary running, increases neurogenesis of granule cells in the dentate gyrus of adult mice. These stimuli are also known to improve performance in hippocampus-dependent learning tasks, but it is unclear whether their effects on neurogenesis are exclusive to the hippocampal formation. In this study, we housed adult mice under three conditions (enriched environment, voluntary wheel running and standard housing), and analysed proliferation in the lateral ventricle wall and granule cell neurogenesis in the olfactory bulb in comparison to the dentate gyrus. Using bromodeoxyuridine to label dividing cells, we could not detect any difference in the number of newly generated cells in the ventricle wall. When giving the new cells time to migrate and differentiate in the olfactory bulb, we observed no changes in the number of adult-generated olfactory granule cells; however, voluntary running and enrichment produced a doubling in the amount of new hippocampal granule cells. The discrepancy between the olfactory bulb and the dentate gyrus suggests that these living conditions trigger locally through an as yet unidentified mechanism specific to neurogenic signals in the dentate gyrus.

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