Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Light-sensing via hydrogen peroxide and a peroxiredoxin

Artikel i vetenskaplig tidskrift
Författare Kristofer Bodvard
Ken Peeters
Friederike Roger
N. Romanov
A. Igbaria
Niek Welkenhuysen
G. Palais
W. Reiter
M. B. Toledano
Mikael Käll
Mikael Molin
Publicerad i Nature Communications
Volym 8
ISSN 2041-1723
Publiceringsår 2017
Publicerad vid Institutionen för kemi och molekylärbiologi
Språk English
Länkar doi.org/10.1038/ncomms14791
Ämnesord yeast transcription factor, saccharomyces-cerevisiae, nuclear-localization, circadian-rhythms, protein-kinase, life-span, glucose starvation, gene disruption, core component, factor msn2p, Science & Technology - Other Topics
Ämneskategorier Biokemi och molekylärbiologi

Sammanfattning

Yeast lacks dedicated photoreceptors; however, blue light still causes pronounced oscillations of the transcription factor Msn2 into and out of the nucleus. Here we show that this poorly understood phenomenon is initiated by a peroxisomal oxidase, which converts light into a hydrogen peroxide (H2O2) signal that is sensed by the peroxiredoxin Tsa1 and transduced to thioredoxin, to counteract PKA-dependent Msn2 phosphorylation. Upon H2O2, the nuclear retention of PKA catalytic subunits, which contributes to delayed Msn2 nuclear concentration, is antagonized in a Tsa1-dependent manner. Conversely, peroxiredoxin hyperoxidation interrupts the H2O2 signal and drives Msn2 oscillations by superimposing on PKA feedback regulation. Our data identify a mechanism by which light could be sensed in all cells lacking dedicated photoreceptors. In particular, the use of H2O2 as a second messenger in signalling is common to Msn2 oscillations and to light-induced entrainment of circadian rhythms and suggests conserved roles for peroxiredoxins in endogenous rhythms.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?