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Abnormal vascular and neural retinal morphology in congenital lifetime isolated growth hormone deficiency

Artikel i vetenskaplig tidskrift
Författare Virginia M. Pereira-Gurgel
Augusto C N Faro
Roberto Salvatori
Thiago A. Chagas
José F. Carvalho-Junior
Carla R P Oliveira
Ursula M M Costa
Gustavo B. Melo
Ann Hellström
Manuel H. Aguiar-Oliveira
Publicerad i Growth Hormone and IGF Research
Volym 30-31
Sidor 11-15
ISSN 1096-6374
Publiceringsår 2016
Publicerad vid Institutionen för neurovetenskap och fysiologi
Sidor 11-15
Språk en
Länkar doi.org/10.1016/j.ghir.2016.07.001
Ämnesord GH, IGF-I, Isolated GH deficiency, Retina
Ämneskategorier Oftalmologi

Sammanfattning

© 2016 Elsevier LtdObjective Experimental models demonstrate an important role of GH in retinal development. However, the interactions between GH and the neuro-vascularization of the human retina are still not clear. A model of untreated congenital isolated GH deficiency (IGHD) may clarify the actions of GH on the retina. The purpose of this work was to assess the retinal neuro-vascularization in untreated congenital IGHD (cIGHD). Design In a cross sectional study, we performed an endocrine and ophthalmological assessment of 25 adult cIGHD subjects, homozygous for a null mutation (c.57 + 1G > A) in the GHRH receptor gene and 28 matched controls. Intraocular pressure measurement, retinography (to assess the number of retinal vascular branching points and the optic disc and cup size), and optical coherence tomography (to assess the thickness of macula) were performed. Results cIGHD subjects presented a more significant reduction of vascular branching points in comparison to controls (91% vs. 53% [p = 0.049]). The percentage of moderate reduction was higher in cIGHD than in controls (p = 0.01). The percentage of individuals with increased optic disc was higher in cIGHD subjects in comparison to controls (92.9% vs. 57.1%). The same occurred for cup size (92.9% vs. 66.7%), p < 0.0001 in both cases. There was no difference in macula thickness. Conclusions Most cIGHD individuals present moderate reduction of vascular branching points, increase of optic disc and cup size, but have similar thickness of the macula.

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