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Changes in HbA(1c) and circulating and adipose tissue androgen levels in overweight-obese women with polycystic ovary syndrome in response to electroacupuncture

Artikel i vetenskaplig tidskrift
Författare Elisabet Stener-Victorin
M. Maliqueo
M. Soligo
V. Protto
L. Manni
Elisabeth Jerlhag
Milana Kokosar
Antonina Sazonova
Carl Johan Behre
Marcus Lind
Claes Ohlsson
K. Hojlund
Anna Benrick
Publicerad i Obesity Science & Practice
Volym 2
Nummer/häfte 4
Sidor 426-435
ISSN 2055-2238
Publiceringsår 2016
Publicerad vid Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi
Centre for Bone and Arthritis Research
Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi
Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition
Institutionen för medicin, avdelningen för molekylär och klinisk medicin
Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi
Sidor 426-435
Språk en
Länkar dx.doi.org/10.1002/osp4.78
https://gup.ub.gu.se/file/206883
Ämnesord Acupuncture, adipose tissue, hyperandrogenism, insulin resistance, sympathetic nervous system, RANDOMIZED CONTROLLED-TRIAL, LOW-FREQUENCY ELECTROACUPUNCTURE, SYMPATHETIC-NERVE ACTIVITY, INSULIN SENSITIVITY, PHYSICAL-EXERCISE, METABOLIC SYNDROME, DIABETES-MELLITUS, GENE-EXPRESSION, RAT MODEL, ACUPUNCTURE
Ämneskategorier Endokrinologi och diabetes, Fysiologi

Sammanfattning

Aim Insulin sensitivity is similar to 40% lower in women with polycystic ovary syndrome (PCOS) than in controls. We tested the hypothesis that 5 weeks of electroacupuncture treatment improves glucose regulation and androgen levels in overweight/obese women with PCOS. Seventeen women with PCOS, aged 18 to 38years, with a body mass index (BMI) >= 25 kg/m(2) and diagnosed with PCOS were included in this experimental and feasibility study and subjected to five weeks of electroacupuncture treatments three times/week. The primary outcome was changes in whole-body glucose homeostasis measured by euglycemic hyperinsulinemic clamp before and after the intervention. Secondary outcome were changes in HbA(1c), circulating catecholamines, adipocyte size and adipose tissue expression of sex steroids and nerve growth factor (NGF). No significant change in glucose homeostasis was observed, but HbA(1c) decreased by 9.5% (p=0.004), circulating testosterone decreased by 22% (p=0.0007) and dihydrotestosterone decreased by 12% (p=0.007). The two vagal activity markers of plasma serotonin levels and the dopamine metabolite homovanillic acid decreased by 21% (p=0.027) and 20% (p=0.011), respectively. Adipose tissue concentrations of testosterone decreased by 18% (p=0.049), and androstenedione decreased by 13% (p=0.035), and mature NGF/proNGF ratio, a marker of sympathetic activity, increased (p=0.04). These changes occurred without changes in anthropometrics. Five weeks of electroacupuncture treatment improves HbA(1c) and circulating and adipose tissue androgens in women with PCOS. This effect is mediated, at least in part, via modulation of vagal activity and adipose tissue sympathetic activity. Based on these findings, we have recently initiated a randomized controlled study (NTC02647827).

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