Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Glucose metabolism and PI… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Glucose metabolism and PIB binding in carriers of a His163Tyr presenilin 1 mutation.

Artikel i vetenskaplig tidskrift
Författare Michael Schöll
Ove Almkvist
Karin Axelman
Elka Stefanova
Anders Wall
Eric Westman
Bengt Långström
Lars Lannfelt
Caroline Graff
Agneta Nordberg
Publicerad i Neurobiology of aging
Volym 32
Nummer/häfte 8
Sidor 1388-99
ISSN 1558-1497
Publiceringsår 2011
Publicerad vid
Sidor 1388-99
Språk en
Länkar dx.doi.org/10.1016/j.neurobiolaging...
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adult, Age of Onset, Aged, Aged, 80 and over, Alzheimer Disease, diagnostic imaging, genetics, metabolism, Benzothiazoles, Blood Glucose, metabolism, Carbon Radioisotopes, Corpus Striatum, diagnostic imaging, metabolism, Female, Humans, Male, Middle Aged, Point Mutation, genetics, Positron-Emission Tomography, methods, Presenilin-1, genetics, metabolism
Ämneskategorier Medicinsk bioteknologi, Klinisk medicin

Sammanfattning

Six young related pre-symptomatic carriers of a His163Tyr mutation in the presenilin 1 gene who will develop early onset familial Alzheimer's disease (eoFAD), and a control group of 23 non-carriers underwent (18)F-fluorodeoxyglucose positron emission tomography (FDG PET). The mutation carriers were followed-up after 2 years. Multivariate analysis showed clear separation of carriers from non-carriers on both occasions, with the right thalamus being the region contributing most to group differentiation. Statistical parametric mapping (SPM) revealed in the carriers non-significantly lower thalamic cerebral glucose metabolism (CMRglc) at baseline and significantly decreased CMRglc in the right thalamus at follow-up. One mutation carrier was followed-up with FDG PET 10 years after baseline and showed reductions in cognition and CMRglc in the posterior cingulate and the frontal cortex. This subject was diagnosed with AD 1 year later and assessed with an additional FDG as well as an (11)C-PIB PET scan 12 years after baseline. Global cortical CMRglc and cognition were distinctly decreased. PIB binding was comparable with sporadic AD patterns but showing slightly higher striatal levels.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?