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Maltreatment-associated neurodevelopmental disorders: a co-twin control analysis.

Artikel i vetenskaplig tidskrift
Författare Lisa Dinkler
Sebastian Lundström
Ruchika Gajwani
Paul Lichtenstein
Christopher Gillberg
Helen Minnis
Publicerad i Journal of child psychology and psychiatry, and allied disciplines
Volym 58
Nummer/häfte 6
Sidor 691-701
ISSN 1469-7610
Publiceringsår 2017
Publicerad vid Gillbergcentrum
Centrum för etik, juridik och mental hälsa
Sidor 691-701
Språk en
Länkar dx.doi.org/10.1111/jcpp.12682
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Child maltreatment; behavior genetics; child abuse; co-twin control design; neurodevelopmental disorders
Ämneskategorier Barn- och ungdomspsykiatri

Sammanfattning

Childhood maltreatment (CM) is strongly associated with psychiatric disorders in childhood and adulthood. Previous findings suggest that the association between CM and psychiatric disorders is partly causal and partly due to familial confounding, but few studies have investigated the mechanisms behind the association between CM and neurodevelopmental disorders (NDDs). Our objective was to determine whether maltreated children have an elevated number of NDDs and whether CM is a risk factor for an increased NDD 'load' and increased NDD symptoms when controlling for familial effects.We used a cross-sectional sample from a population-representative Swedish twin study, comprising 8,192 nine-year-old twins born in Sweden between 1997 and 2005. CM was defined as parent-reported exposure to emotional abuse/neglect, physical neglect, physical abuse, and/or sexual abuse. Four NDDs were measured with the Autism-Tics, AD/HD, and other comorbidities inventory.Maltreated children had a greater mean number of NDDs than nonmaltreated children. In a co-twin control design, CM-discordant monozygotic twins did not differ significantly for their number of NDDs, suggesting that CM is not associated with an increased load of NDDs when genetic and shared environmental factors are taken into account. However, CM was associated with a small increase in symptoms of attention-deficit/hyperactivity disorder and autism spectrum disorder in CM-discordant MZ twins, although most of the covariance of CM with NDD symptoms was explained by common genetic effects.Maltreated children are at higher risk of having multiple NDDs. Our findings are, however, not consistent with the notion that CM causes the increased NDD load in maltreated children. Maltreated children should receive a full neurodevelopmental assessment, and clinicians should be aware that children with multiple NDDs are at higher risk of maltreatment.

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