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Long-term treatment with methylphenidate for fatigue after traumatic brain injury

Artikel i vetenskaplig tidskrift
Författare Birgitta Johansson
Anna-Pia Wentzel
Paulin Andréll
Lars Rönnbäck
C. Mannheimer
Publicerad i Acta Neurologica Scandinavica
Volym 135
Nummer/häfte 1
Sidor 100-107
ISSN 0001-6314
Publiceringsår 2017
Publicerad vid Institutionen för neurovetenskap och fysiologi
Institutionen för medicin, avdelningen för molekylär och klinisk medicin
Sidor 100-107
Språk en
Ämnesord cognition, mental fatigue, methylphenidate, traumatic brain injury, randomized controlled-trial, mental fatigue, double-blind, attention, deficits, head-injury, vital signs, safety, adults, mild, rehabilitation, Neurosciences & Neurology, ice dd, 1983, pain, v17, p45
Ämneskategorier Neurologi

Sammanfattning

Objectives - Traumatic brain injury (TBI) may cause long-lasting post-concussive symptoms, such as mental fatigue and concentration difficulties, and this may become the main hindrance for returning to work and studies. There is currently no effective treatment for longlasting mental fatigue. In this hypothesis generating study, the long-term effects of methylphenidate on mental fatigue, cognitive function, and safety were assessed. Materials & methods - Thirty participants who suffered from long-term post-concussion symptoms after a mild TBI or moderate TBI and who had reported positive effects with methylphenidate during an initial phase of this follow-up study were treated with methylphenidate for a further six months. Results - After six-month follow-up, effects on Mental Fatigue Scale (MFS), depression, anxiety, and cognitive function (processing speed, attention, working memory) were significantly improved compared to baseline data (P < 0.001, respectively). Heart rate was significantly increased (P = 0.01), while blood pressure was not changed. Conclusions - Individuals suffering from prolonged symptoms after TBI reported reduced mental fatigue and improved cognitive functions with long-term methylphenidate treatment. It is suggested that methylphenidate can be a treatment option for long-term mental fatigue and cognitive impairment after a TBI, but further randomized control research is warranted.

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